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PMID: 12612652 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Review

RecQ helicases: caretakers of the genome.

Nature reviews. Cancer ·Vol. 3 ·No. 3 ·2003-03-00 ·Pages 169-78

Hickson ID

Abstract

RecQ helicases are highly conserved from bacteria to man. Germline mutations in three of the five known family members in humans give rise to debilitating disorders that are characterized by, amongst other things, a predisposition to the development of cancer. One of these disorders--Bloom's syndrome--is uniquely associated with a predisposition to cancers of all types. So how do RecQ helicases protect against cancer? They seem to maintain genomic stability by functioning at the interface between DNA replication and DNA repair.

MeSH Terms

Adenosine Triphosphatases/chemistry,deficiency,genetics,physiology Animals Bloom Syndrome/enzymology,genetics Cell Transformation, Neoplastic/genetics DNA Helicases/chemistry,deficiency,genetics,physiology DNA Repair/genetics,physiology DNA Replication/genetics,physiology Escherichia coli Proteins/genetics,physiology Exodeoxyribonucleases Genes, Tumor Suppressor Genetic Predisposition to Disease Humans Mice Mice, Knockout Multienzyme Complexes/physiology Mutagenesis/genetics Protein Interaction Mapping Protein Structure, Tertiary RecQ Helicases Rothmund-Thomson Syndrome/enzymology,genetics Species Specificity Werner Syndrome/enzymology,genetics Werner Syndrome Helicase

Chemicals

Escherichia coli Proteins Multienzyme Complexes Exodeoxyribonucleases Adenosine Triphosphatases Bloom syndrome protein RECQL protein, human RecQ protein, E coli DNA Helicases RecQ Helicases WRN protein, human Werner Syndrome Helicase

Authors & Affiliations

1 authors, click to expand affiliations / ORCID

Hickson Ian D

Cancer Research UK Laboratories, Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DS, UK. ian.hickson@cancer.org.uk

Article Info

Journal

Nature reviews. Cancer

Abbr.

Nat Rev Cancer

ISSN

1474-175X

DOI

10.1038/nrc1012

ian.hickson@cancer.org.uk

Published

2003-03-00

Pages

169-78

Language

English

Region

England

NLM ID

101124168

Subset

External Links

PubMed source DOI: 10.1038/nrc1012 View journal details

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