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PMID: 12612601 Published · ppublish English Journal Article Review

Modification with SUMO. A role in transcriptional regulation.

EMBO reports ·Vol. 4 ·No. 2 ·2003-02-00 ·Pages 137-42

Verger A, Perdomo J, Crossley M

Abstract

Small ubiquitin-related modifier (SUMO) is a protein moiety that is ligated to lysine residues in a variety of target proteins. The addition of SUMO can modulate the ability of proteins to interact with their partners, alter their patterns of subcellular localization and control their stability. It is clear that SUMO influences many different biological processes, but recent data suggest that it is particularly important in the regulation of transcription. Indeed, several transcription factors, such as Sp3, c-Jun, c-Myb and various nuclear receptors, have recently been shown to be subject to sumoylation and, although this modification can have a positive influence, a growing body of evidence highlights its role in the negative regulation of transcription. This review summarizes recent experiments focusing on sumoylation and transcriptional repression.

MeSH Terms
Gene Expression Regulation/physiology Humans Protein Structure, Tertiary Small Ubiquitin-Related Modifier Proteins/metabolism Transcription, Genetic/physiology
Chemicals
Small Ubiquitin-Related Modifier Proteins
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Verger Alexis
School of Molecular and Microbial Biosciences G08, University of Sydney, Sydney, NSW, 2006, Australia. a.verger@mmb.usyd.edu.au
Perdomo José
Crossley Merlin
References (47)
47 references, click to expand
  1. Regulation of heat shock transcription factor 1 by stress-induced SUMO-1 modification.
    J Biol Chem. 2001 Oct 26;276(43):40263-7 PMID: 11514557
  2. Ubc9 interacts with the androgen receptor and activates receptor-dependent transcription.
    J Biol Chem. 1999 Jul 2;274(27):19441-6 PMID: 10383460
  3. PIASy, a nuclear matrix-associated SUMO E3 ligase, represses LEF1 activity by sequestration into nuclear bodies.
    Genes Dev. 2001 Dec 1;15(23):3088-103 PMID: 11731474
  4. The nucleoporin RanBP2 has SUMO1 E3 ligase activity.
    Cell. 2002 Jan 11;108(1):109-20 PMID: 11792325
  5. Transcription factor Sp3 is regulated by acetylation.
    Nucleic Acids Res. 2001 Dec 15;29(24):4994-5000 PMID: 11812829
  6. Activation of p53 by protein inhibitor of activated Stat1 (PIAS1).
    J Biol Chem. 2002 Mar 8;277(10):8255-9 PMID: 11788578
  7. Members of the PIAS family act as SUMO ligases for c-Jun and p53 and repress p53 activity.
    Proc Natl Acad Sci U S A. 2002 Mar 5;99(5):2872-7 PMID: 11867732
  8. Covalent attachment of the SUMO-1 protein to the negative regulatory domain of the c-Myb transcription factor modifies its stability and transactivation capacity.
    J Biol Chem. 2002 Mar 15;277(11):8999-9009 PMID: 11779867
  9. Modification of the human thymine-DNA glycosylase by ubiquitin-like proteins facilitates enzymatic turnover.
    EMBO J. 2002 Mar 15;21(6):1456-64 PMID: 11889051
  10. Ubiquitin-related modifier SUMO1 and nucleocytoplasmic transport.
    Traffic. 2002 Jun;3(6):381-7 PMID: 12010456
  11. Versatile protein tag, SUMO: its enzymology and biological function.
    J Cell Physiol. 2002 Jun;191(3):257-68 PMID: 12012321
  12. The SUMO E3 ligase RanBP2 promotes modification of the HDAC4 deacetylase.
    EMBO J. 2002 Jun 3;21(11):2682-91 PMID: 12032081
  13. The ETS domain transcription factor Elk-1 contains a novel class of repression domain.
    Mol Cell Biol. 2002 Jul;22(14):5036-46 PMID: 12077333
  14. PIAS proteins modulate transcription factors by functioning as SUMO-1 ligases.
    Mol Cell Biol. 2002 Jul;22(14):5222-34 PMID: 12077349
  15. SUMO-1 modification of histone deacetylase 1 (HDAC1) modulates its biological activities.
    J Biol Chem. 2002 Jun 28;277(26):23658-63 PMID: 11960997
  16. The nuclear receptor interaction domain of GRIP1 is modulated by covalent attachment of SUMO-1.
    J Biol Chem. 2002 Aug 16;277(33):30283-8 PMID: 12060666
  17. Transcription factor AP-2 interacts with the SUMO-conjugating enzyme UBC9 and is sumolated in vivo.
    J Biol Chem. 2002 Aug 23;277(34):30798-804 PMID: 12072434
  18. The inhibitory function in human progesterone receptor N termini binds SUMO-1 protein to regulate autoinhibition and transrepression.
    J Biol Chem. 2002 Sep 13;277(37):33950-6 PMID: 12114521
  19. RAD6-dependent DNA repair is linked to modification of PCNA by ubiquitin and SUMO.
    Nature. 2002 Sep 12;419(6903):135-41 PMID: 12226657
  20. Transcription factor Sp3 is silenced through SUMO modification by PIAS1.
    EMBO J. 2002 Oct 1;21(19):5206-15 PMID: 12356736
  21. Transcriptional activity of CCAAT/enhancer-binding proteins is controlled by a conserved inhibitory domain that is a target for sumoylation.
    J Biol Chem. 2002 Oct 11;277(41):38037-44 PMID: 12161447
  22. Small ubiquitin-related modifier-1 (SUMO-1) modification of the glucocorticoid receptor.
    Biochem J. 2002 Nov 1;367(Pt 3):907-11 PMID: 12144530
  23. PIAS1 and PIASxalpha function as SUMO-E3 ligases toward androgen receptor and repress androgen receptor-dependent transcription.
    J Biol Chem. 2002 Nov 1;277(44):41311-7 PMID: 12177000
  24. SUMO-1 modification represses Sp3 transcriptional activation and modulates its subnuclear localization.
    Mol Cell. 2002 Oct;10(4):831-42 PMID: 12419227
  25. SUMO-1 protease-1 regulates gene transcription through PML.
    Mol Cell. 2002 Oct;10(4):843-55 PMID: 12419228
  26. Preferential interaction of sentrin with a ubiquitin-conjugating enzyme, Ubc9.
    J Biol Chem. 1997 Nov 7;272(45):28198-201 PMID: 9353268
  27. SUMO-1 modification and its role in targeting the Ran GTPase-activating protein, RanGAP1, to the nuclear pore complex.
    J Cell Biol. 1998 Feb 9;140(3):499-509 PMID: 9456312
  28. SUMO-1 modification of IkappaBalpha inhibits NF-kappaB activation.
    Mol Cell. 1998 Aug;2(2):233-9 PMID: 9734360
  29. Modulation of TEL transcription activity by interaction with the ubiquitin-conjugating enzyme UBC9.
    Proc Natl Acad Sci U S A. 1999 Jun 22;96(13):7467-72 PMID: 10377438
  30. A common motif within the negative regulatory regions of multiple factors inhibits their transcriptional synergy.
    Mol Cell Biol. 2000 Aug;20(16):6040-50 PMID: 10913186
  31. Biochemistry. All in the ubiquitin family.
    Science. 2000 Jul 28;289(5479):563-4 PMID: 10939967
  32. Covalent modification of the transactivator protein IE2-p86 of human cytomegalovirus by conjugation to the ubiquitin-homologous proteins SUMO-1 and hSMT3b.
    J Virol. 2000 Mar;74(6):2510-24 PMID: 10684265
  33. Functional heterogeneity of small ubiquitin-related protein modifiers SUMO-1 versus SUMO-2/3.
    J Biol Chem. 2000 Mar 3;275(9):6252-8 PMID: 10692421
  34. A novel transcriptional repression domain mediates p21(WAF1/CIP1) induction of p300 transactivation.
    Mol Cell Biol. 2000 Apr;20(8):2676-86 PMID: 10733570
  35. c-Jun and p53 activity is modulated by SUMO-1 modification.
    J Biol Chem. 2000 May 5;275(18):13321-9 PMID: 10788439
  36. SUMO--nonclassical ubiquitin.
    Annu Rev Cell Dev Biol. 2000;16:591-626 PMID: 11031248
  37. Covalent modification of p73alpha by SUMO-1. Two-hybrid screening with p73 identifies novel SUMO-1-interacting proteins and a SUMO-1 interaction motif.
    J Biol Chem. 2000 Nov 17;275(46):36316-23 PMID: 10961991
  38. Covalent modification of the androgen receptor by small ubiquitin-like modifier 1 (SUMO-1).
    Proc Natl Acad Sci U S A. 2000 Dec 19;97(26):14145-50 PMID: 11121022
  39. Themes and variations on ubiquitylation.
    Nat Rev Mol Cell Biol. 2001 Mar;2(3):169-78 PMID: 11265246
  40. SUMO, ubiquitin's mysterious cousin.
    Nat Rev Mol Cell Biol. 2001 Mar;2(3):202-10 PMID: 11265250
  41. Sumo-1 modification regulates the DNA binding activity of heat shock transcription factor 2, a promyelocytic leukemia nuclear body associated transcription factor.
    J Biol Chem. 2001 May 25;276(21):18513-8 PMID: 11278381
  42. The small ubiquitin-like modifier-1 (SUMO-1) consensus sequence mediates Ubc9 binding and is essential for SUMO-1 modification.
    J Biol Chem. 2001 Jun 15;276(24):21664-9 PMID: 11259410
  43. Regulation of transcriptional activation domain function by ubiquitin.
    Science. 2001 Aug 31;293(5535):1651-3 PMID: 11463878
  44. Polymeric chains of SUMO-2 and SUMO-3 are conjugated to protein substrates by SAE1/SAE2 and Ubc9.
    J Biol Chem. 2001 Sep 21;276(38):35368-74 PMID: 11451954
  45. An E3-like factor that promotes SUMO conjugation to the yeast septins.
    Cell. 2001 Sep 21;106(6):735-44 PMID: 11572779
  46. Involvement of PIAS1 in the sumoylation of tumor suppressor p53.
    Mol Cell. 2001 Sep;8(3):713-8 PMID: 11583632
  47. SUMO: of branched proteins and nuclear bodies.
    Oncogene. 2001 Oct 29;20(49):7243-9 PMID: 11704852
Article Info
Journal
EMBO reports
Abbr.
EMBO Rep
ISSN
1469-221X
DOI
10.1038/sj.embor.embor738
Email
a.verger@mmb.usyd.edu.au
Published
2003-02-00
Pages
137-42
Language
English
Region
England
NLM ID
100963049
PMCID
PMC1315836
Subset
IM
External Links
PubMed source DOI: 10.1038/sj.embor.embor738 PMC Full Text View journal details
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