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题目:: Evaluation of familial clustering of breast and prostate cancer in the Minnesota Breast Cancer Family Study.
作者:: Grabrick(Dawn M),Cerhan(James R),Vierkant(Robert A),Therneau(Terry M),Cheville(John C),Tindall(Donald J),Sellers(Thomas A)
状态:: 发布时间2003-02-25 , 更新时间 2007-11-14
期刊:: Cancer Detect Prev
摘要:: Few studies examining familial clustering of breast and prostate cancer (PC) have focused on a clearly defined high-risk population with epidemiologic risk factors. We conducted a cohort study of prostate cancer among a subset of 426 families ascertained through female breast cancer probands. Three groups of males were included: 804 relatives in 60 families with four or more breast or ovarian cancers, 536 marry-ins in these high-risk families, and 484 relatives in 81 families where only the proband had breast cancer. A total of 118 prostate cancers were reported. The rate of prostate cancer among blood relatives in high-risk families was significantly lower than among marry-ins (RR = 0.6, 95% C.I.: 0.4-0.9). The rate of prostate cancer among blood relatives in low-risk families was not significantly different from the rate among marry-ins (RR = 0.8, 95% C.I.: 0.5-1.2). These results provide little evidence that male relatives in high-risk breast cancer families are at increased risk of prostate cancer.
语言:: eng
DOI:

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