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PMID: 12598659 Published · ppublish English Comparative Study Journal Article Research Support, U.S. Gov't, P.H.S. Review

Non-heme iron enzymes: contrasts to heme catalysis.

Solomon EI, Decker A, Lehnert N

Abstract

Non-heme iron enzymes catalyze a wide range of O(2) reactions, paralleling those of heme systems. Non-heme iron active sites are, however, much more difficult to study because they do not exhibit the intense spectral features characteristic of the porphyrin ligand. A spectroscopic methodology was developed that provides significant mechanistic insight into the reactivity of non-heme ferrous active sites. These studies reveal a general mechanistic strategy used by these enzymes and differences in substrate and cofactor interactions dependent on their requirement for activation by iron. Contributions to O(2) activation have been elucidated for non-heme relative to heme ligand sets, and major differences in reactivity are defined with respect to the heterolytic and homolytic cleavage of O-O bonds.

MeSH Terms
Binding Sites Enzymes/chemistry,metabolism Heme/metabolism Hydrogen Bonding Iron/metabolism Ligands Phenylalanine Hydroxylase/chemistry,metabolism Porphyrins/metabolism Thermodynamics
Chemicals
Enzymes Ligands Porphyrins Heme Iron Phenylalanine Hydroxylase
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Solomon Edward I
Department of Chemistry, Stanford University, Stanford, CA 94305, USA. edward.solomon@stanford.edu
Decker Andrea
Lehnert Nicolai
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Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
Published
2003-04-01
Epub
2003-00-21
Pages
3589-94
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC152966
Subset
IM
Grants
NIGMS NIH HHS · R01 GM040392 · United States
NIGMS NIH HHS · GM-40392 · United States
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