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PMID: 12591911 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Review

Is all of the endoplasmic reticulum created equal? The effects of the heterogeneous distribution of endoplasmic reticulum Ca2+-handling proteins.

The Journal of cell biology ·Vol. 160 ·No. 4 ·2003-02-17 ·Pages 475-9

Papp S, Dziak E, Michalak M, Opas M

Abstract

The endoplasmic reticulum is a heterogeneous compartment with respect to the distribution of its Ca2+-handling proteins, namely the Ca2+-binding proteins, the Ca2+ pumps and the Ca2+ release channels. The nonuniform distribution of these proteins may explain the functional heterogeneity of the endoplasmic reticulum, such as the generation of spatially complex Ca2+ signals, Ca2+ homeostasis, and protein folding and quality control.

MeSH Terms
Animals Calcium/metabolism Calcium Channels/metabolism Calcium Signaling/physiology Calcium-Binding Proteins/metabolism Endoplasmic Reticulum/metabolism Fibroblasts/cytology,metabolism Homeostasis Humans Molecular Chaperones/metabolism Oocytes/cytology,metabolism
Chemicals
Calcium Channels Calcium-Binding Proteins Molecular Chaperones Calcium
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Papp S
Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada M5S 1A8. sylvia.papp@utoronto.ca
Dziak E
Michalak M
Opas M
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Article Info
Journal
The Journal of cell biology
Abbr.
J Cell Biol
ISSN
0021-9525
DOI
10.1083/jcb.200207136
Email
sylvia.papp@utoronto.ca
Published
2003-02-17
Pages
475-9
Language
English
Region
United States
NLM ID
0375356
PMCID
PMC2173736
Subset
IM
External Links
PubMed source DOI: 10.1083/jcb.200207136 PMC Full Text View journal details
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