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题目:: Spread of HTLV-I between lymphocytes by virus-induced polarization of the cytoskeleton.
作者:: Igakura(Tadahiko),Stinchcombe(Jane C),Goon(Peter K C),Taylor(Graham P),Weber(Jonathan N),Griffiths(Gillian M),Tanaka(Yuetsu),Osame(Mitsuhiro),Bangham(Charles R M)
状态:: 发布时间2003-03-14 , 更新时间 2007-03-19
期刊:: Science
摘要:: Cell contact is required for efficient transmission of human T cell leukemia virus- type 1 (HTLV-I) between cells and between individuals, because naturally infected lymphocytes produce virtually no cell-free infectious HTLV-I particles. However, the mechanism of cell-to-cell spread of HTLV-I is not understood. We show here that cell contact rapidly induces polarization of the cytoskeleton of the infected cell to the cell-cell junction. HTLV-I core (Gag protein) complexes and the HTLV-I genome accumulate at the cell-cell junction and are then transferred to the uninfected cell. Other lymphotropic viruses, such as HIV-1, may similarly subvert normal T cell physiology to allow efficient propagation between cells.
语言:: eng
DOI:

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