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PMID: 12574123 Published · ppublish English Journal Article Research Support, U.S. Gov't, Non-P.H.S. Research Support, U.S. Gov't, P.H.S.

Vibrio harveyi quorum sensing: a coincidence detector for two autoinducers controls gene expression.

The EMBO journal ·Vol. 22 ·No. 4 ·2003-02-17 ·Pages 870-81

Mok KC, Wingreen NS, Bassler BL

Abstract

In a process called quorum sensing, bacteria communicate with one another by exchanging chemical signals called autoinducers. In the bioluminescent marine bacterium Vibrio harveyi, two different auto inducers (AI-1 and AI-2) regulate light emission. Detection of and response to the V.harveyi autoinducers are accomplished through two two-component sensory relay systems: AI-1 is detected by the sensor LuxN and AI-2 by LuxPQ. Here we further define the V.harveyi quorum-sensing regulon by identifying 10 new quorum-sensing-controlled target genes. Our examination of signal processing and integration in the V.harveyi quorum-sensing circuit suggests that AI-1 and AI-2 act synergistically, and that the V.harveyi quorum-sensing circuit may function exclusively as a 'coincidence detector' that discriminates between conditions in which both autoinducers are present and all other conditions.

MeSH Terms
4-Butyrolactone/analogs & derivatives,physiology Gene Expression Regulation, Bacterial/physiology Homoserine/analogs & derivatives,physiology Lactones Signal Transduction/physiology Vibrio/genetics,physiology beta-Galactosidase/metabolism
Chemicals
Lactones N-octanoylhomoserine lactone Homoserine N-(3-oxohexanoyl)-3-aminodihydro-2(3H)-furanone beta-Galactosidase 4-Butyrolactone
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Mok Kenny C
Department of Molecular Biology, Princeton University, Princeton, NJ 08544-1014, USA.
Wingreen Ned S
Bassler Bonnie L
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41 references, click to expand
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Article Info
Journal
The EMBO journal
Abbr.
EMBO J
ISSN
0261-4189
DOI
10.1093/emboj/cdg085
Published
2003-02-17
Pages
870-81
Language
English
Region
England
NLM ID
8208664
PMCID
PMC145445
Subset
IM
Grants
NIGMS NIH HHS · R01 GM065859 · United States
NIGMS NIH HHS · R37 GM065859 · United States
NIGMS NIH HHS · GM65859 · United States
External Links
PubMed source DOI: 10.1093/emboj/cdg085 PMC Full Text View journal details
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