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题目:: Cell-surface-expressed HIV-1 envelope induces the death of CD4 T cells during GP41-mediated hemifusion-like events.
作者:: Blanco(Julià),Barretina(Jordi),Ferri(Karine F),Jacotot(Etienne),Gutiérrez(Arantxa),Armand-Ugón(Mercedes),Cabrera(Cecilia),Kroemer(Guido),Clotet(Bonaventura),Esté(José A)
状态:: 发布时间2003-02-07 , 更新时间 2006-11-15
期刊:: Virology
摘要:: Cells expressing the HIV-1 envelope glycoprotein complex (gp120/gp41, Env) induce the death of target cells either after cell-to-cell fusion or after cell-to-cell contact in a fusion-independent fashion. Here, we demonstrate that Env-induced death of single cells (including primary CD4 T cells) required gp120 and gp41 function. The gp41 peptide C34, which blocked syncytium formation, completely inhibited the death of single target cells by specifically acting on gp41 function. Moreover, Env-induced single cell death was exclusively observed in CD4 cells and was associated with specific gp41-mediated transfer of lipids from the membrane of Env-expressing cells to the target cell but not with detectable cytoplasm mixing (complete fusion). We conclude that after gp120 function, gp41 mediates close cell-to-cell contacts, thereby triggering cell death in single uninfected cells in the absence of detectable cell-to-cell fusion.
语言:: eng
DOI:

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