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PMID: 12570998 Published · ppublish English Evaluation Study Journal Article Research Support, Non-U.S. Gov't

A sensitive and inexpensive yeast bioassay for the mycotoxin zearalenone and other compounds with estrogenic activity.

Applied and environmental microbiology ·Vol. 69 ·No. 2 ·2003-02-00 ·Pages 805-11

Mitterbauer R, Weindorfer H, Safaie N, Krska R, Lemmens M, Ruckenbauer P, Kuchler K, Adam G

Abstract

Zearalenone (ZON) is a nonsteroidal estrogenic mycotoxin produced by plant-pathogenic species of Fusarium. As a consequence of infection with Fusarium culmorum and Fusarium graminearum, ZON can be found in cereals and derived food products. Since ZON is suspected to be a cause of human disease, including premature puberty syndrome, as well as hyperestrogenism in farm animals, several countries have established monitoring programs and guidelines for ZON levels in grain intended for human consumption and animal feed. We developed a low-cost method for monitoring ZON contamination in grain based on a sensitive yeast bioassay. The indicator Saccharomyces cerevisiae strain YZRM7 is unable to grow unless an engineered pyrimidine biosynthetic gene is activated by the expressed human estrogen receptor in the presence of exogenous estrogenic substances. Deletion of the genes encoding ATP-binding cassette (ABC) transporters Pdr5p and Snq2p increases net ZON uptake synergistically. Less than 1 microg of ZON per liter of medium is sufficient to allow growth of the indicator strain. To prevent interference with pyrimidines potentially present in biological samples, we also disrupted the genes FUR1 and URK1, blocking the pyrimidine salvage pathway. The bioassay strain YZRM7 allows qualitative detection and quantification of total estrogenic activity in cereal extracts without requiring further cleanup steps. Its high sensitivity makes this assay suitable for low-cost monitoring of contamination of maize and small grain cereals with estrogenic Fusarium mycotxins.

MeSH Terms
ATP-Binding Cassette Transporters/genetics Biological Assay/economics Estrogens/metabolism Fusarium/metabolism Gene Deletion Humans Mycotoxins/analysis Pyrimidines/metabolism Receptors, Estrogen/genetics,metabolism Saccharomyces cerevisiae/genetics,growth & development,metabolism Saccharomyces cerevisiae Proteins/genetics Sensitivity and Specificity Triticum/chemistry Zea mays/chemistry Zearalenone/analysis
Chemicals
ATP-Binding Cassette Transporters Estrogens Mycotoxins PDR5 protein, S cerevisiae Pyrimidines Receptors, Estrogen SNQ2 protein, S cerevisiae Saccharomyces cerevisiae Proteins Zearalenone pyrimidine
Authors & Affiliations
8 authors, click to expand affiliations / ORCID
Mitterbauer Rudolf
Center of Applied Genetics, University of Agricultural Sciences, A-1190 Vienna, Austria.
Weindorfer Hanna
Safaie Naser
Krska Rudolf
Lemmens Marc
Ruckenbauer Peter
Kuchler Karl
Adam Gerhard
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Article Info
Journal
Applied and environmental microbiology
Abbr.
Appl Environ Microbiol
ISSN
0099-2240
Published
2003-02-00
Pages
805-11
Language
English
Region
United States
NLM ID
7605801
PMCID
PMC143629
Subset
IM
Analysis Services
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