Home LiteratureArticle Details

PMID: 12563277 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Native Myosin-IXb is a plus-, not a minus-end-directed motor.

Nature cell biology ·Vol. 5 ·No. 2 ·2003-02-00 ·Pages 171-2

O'Connell CB, Mooseker MS

Abstract

Myosin-IXb (Myo9b) is a single-headed, processive motor that contains a Rho-GTPase-activating protein (GAP) domain within its tail. Although tail-less myosin- IXb motor domain moves towards the minus end of the actin filament, we show here that full-length myosin-IXb is a plus-end-directed motor. This suggests that the tail domain of myosin-IXb regulates motor directionality.

MeSH Terms

Actins/metabolism Antibodies/metabolism Molecular Motor Proteins/metabolism Myosin Type V/metabolism Myosins/metabolism Protein Structure, Tertiary Time Factors

Chemicals

Actins Antibodies Molecular Motor Proteins myosin IXB Myosin Type V Myosins

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

O'Connell Christopher B

Department of Cell Biology, Yale University School of Medicine, New Haven, CT 06511, USA.

Mooseker Mark S

Article Info

Journal

Nature cell biology

Abbr.

Nat Cell Biol

ISSN

1465-7392

DOI

10.1038/ncb924

Published

2003-02-00

Pages

171-2

Language

English

Region

England

NLM ID

100890575

Subset

Grants

NIDDK NIH HHS · DK 55389 · United States

NIDDK NIH HHS · DK-25387 · United States

External Links

PubMed source DOI: 10.1038/ncb924 View journal details

Analysis Services

Native Myosin-IXb is a plus-, not a minus-end-directed motor.

Contact

WeChat Official Account