The effect of uncouplers on catecholamine incorporation by vesicles of chromaffin granules.

The Biochemical journal ·Vol. 148 ·No. 1 ·1975-04-00 ·Pages 153-5

Bashford CL, Casey RP, Radda GK, Ritchie GA

Abstract

It is shown that uncouplers inhibit the incorporation of catecholamines by vesicles of chromaffin granules in parallel with their stimulatory effect on the membrane-bound adenosine triphosphatase.

MeSH Terms

Adenosine Triphosphatases/analysis Adenosine Triphosphate/metabolism Adrenal Medulla/drug effects,metabolism,ultrastructure Animals Catecholamines/metabolism Cattle Cytoplasmic Granules/drug effects In Vitro Techniques Magnesium/metabolism Uncoupling Agents/pharmacology

Chemicals

Catecholamines Uncoupling Agents Adenosine Triphosphate Adenosine Triphosphatases Magnesium

Authors & Affiliations

4 authors, click to expand affiliations / ORCID

Bashford C L

Casey R P

Radda G K

Ritchie G A

References (8)

8 references, click to expand

Uptake of catecholamines by a particulate fraction of the adrenal medulla.
J Biol Chem. 1962 Jul;237:2311-7 PMID: 14456353
Energy-linked activities of the chromaffin granule membrane.
FEBS Lett. 1975 Jan 15;50(1):21-4 PMID: 234083
The membrane of catecholamine storage vesicles of adrenal medulla. Catecholamines fluxes and ATPase activity.
Naunyn Schmiedebergs Arch Pharmakol. 1971;270(4):392-406 PMID: 4255379
A simple method for the isolation of adrenal chromaffin granules on a large scale.
Biochem J. 1967 May;103(2):480-2 PMID: 6032982
Steady-state kinetics of catecholamine transport by chromaffin-granule "ghosts".
Biochem J. 1974 Nov;144(2):319-25 PMID: 4462585
Transport of catecholamines by resealed chromaffin-grnaule "ghosts".
Biochem J. 1974 Nov;144(2):311-8 PMID: 4477958
Effects of some metabolic co-factors and inhibitors on transmitter release and uptake in isolated adrenergic nerve granules.
Acta Physiol Scand. 1969 Nov;77(3):298-307 PMID: 5372261
Chromogranin A dopamine -hydroxylase and secretion from the adrenal medulla.
Philos Trans R Soc Lond B Biol Sci. 1971 Jun 17;261(839):279-89 PMID: 4399620

Article Info

Journal

The Biochemical journal

Abbr.

Biochem J

ISSN

0264-6021

DOI

10.1042/bj1480153

Published

1975-04-00

Pages

153-5

Language

English

Region

England

NLM ID

2984726R

PMCID

PMC1165517

Subset

External Links

PubMed source DOI: 10.1042/bj1480153 PMC Full Text View journal details

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The effect of uncouplers on catecholamine incorporation by vesicles of chromaffin granules.

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