Controlling the double helix.

Nature ·Vol. 421 ·No. 6921 ·2003-01-23 ·Pages 448-53

Felsenfeld G, Groudine M

Abstract

Chromatin is the complex of DNA and proteins in which the genetic material is packaged inside the cells of organisms with nuclei. Chromatin structure is dynamic and exerts profound control over gene expression and other fundamental cellular processes. Changes in its structure can be inherited by the next generation, independent of the DNA sequence itself.

MeSH Terms

Animals Cell Nucleus/chemistry,genetics Chromatin/chemistry,genetics,metabolism DNA/chemistry,genetics,metabolism DNA Methylation Gene Expression Regulation Histones/chemistry,metabolism Humans Models, Molecular Nucleic Acid Conformation

Chemicals

Chromatin Histones DNA

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Felsenfeld Gary

Laboratory of Molecular Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Building 5, Room 212, Bethesda, Maryland 20892-0540, USA. gary.felsenfeld@nih.gov

Groudine Mark

Article Info

Journal

Nature

Abbr.

Nature

ISSN

0028-0836

DOI

10.1038/nature01411

gary.felsenfeld@nih.gov

Published

2003-01-23

Pages

448-53

Language

English

Region

England

NLM ID

0410462

Subset

External Links

PubMed source DOI: 10.1038/nature01411 View journal details

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Controlling the double helix.

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