The chemical structure of prostaglandin X (prostacyclin).

Prostaglandins ·Vol. 12 ·No. 6 ·1976-12-00 ·Pages 915-28

Whittaker N, Bunting S, Salmon J, Moncada S, Vane JR, Johnson RA, Morton DR, Kinner JH, Gorman RR, McGuire JC, Sun FF

Abstract

The chemical structure of prostaglandin X, the anti-aggregatory substance derived from prostaglandin endoperoxides, is 9-deoxy-6, 6alpha-epoxy-delta5-PGF1alpha. The stable compound formed when prostaglandin X undergoes a chemical transformation in biological systems in 6-keto-PGF1alpha. Prostaglandin X is stabilized in aqueous preparations by raising the pH to 8.5 or higher. The trivial name prostacyclin is proposed for 9-deoxy-6, 9alpha-epoxy-delta5-PGF1alpha.

MeSH Terms

Animals Aorta/metabolism Chemical Phenomena Chemistry Chromatography, Gas Hydrogen-Ion Concentration Mass Spectrometry Microsomes/metabolism Muscle Contraction/drug effects Muscle, Smooth/drug effects Peroxides Platelet Aggregation/drug effects Prostaglandins/pharmacology Prostaglandins F/metabolism,pharmacology Swine

Chemicals

Peroxides Prostaglandins Prostaglandins F

Authors & Affiliations

11 authors, click to expand affiliations / ORCID

Whittaker N

Bunting S

Salmon J

Moncada S

Vane J R

Johnson R A

Morton D R

Kinner J H

Gorman R R

McGuire J C

Sun F F

Article Info

Journal

Prostaglandins

Abbr.

Prostaglandins

ISSN

0090-6980

DOI

10.1016/0090-6980(76)90126-x

Published

1976-12-00

Pages

915-28

Language

English

Region

United States

NLM ID

0320271

Subset

External Links

PubMed source DOI: 10.1016/0090-6980(76)90126-x

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The chemical structure of prostaglandin X (prostacyclin).

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