The role of negative cooperativity and half-of-the-sites reactivity in enzyme regulation.

Alkaline Phosphatase/metabolism Animals Aspartate Carbamoyltransferase/metabolism Binding Sites Enzymes/metabolism Glyceraldehyde-3-Phosphate Dehydrogenases/metabolism Kinetics Ligands Macromolecular Substances Mathematics Muscles/enzymology Phosphotransferases/metabolism Protein Binding Protein Conformation Succinate-CoA Ligases/metabolism X-Ray Diffraction

Enzymes Ligands Macromolecular Substances Glyceraldehyde-3-Phosphate Dehydrogenases Aspartate Carbamoyltransferase Phosphotransferases Alkaline Phosphatase Succinate-CoA Ligases