Electrostatic fasteners hold the T cell receptor-CD3 complex together.

Molecular cell ·Vol. 11 ·No. 1 ·2003-01-00 ·Pages 5-6

Engelman DM

Abstract

Assembly of the T cell receptor includes the formation of trimers stabilized by electrostatic interactions inside the membrane (Call et al., 2003). Such interactions can strongly stabilize subunit associations while permitting conformation changes during signaling.

MeSH Terms

CD3 Complex/chemistry,immunology Macromolecular Substances Models, Molecular Protein Conformation Receptor-CD3 Complex, Antigen, T-Cell/chemistry,metabolism Receptors, Antigen, T-Cell/chemistry,immunology Signal Transduction Static Electricity

Chemicals

CD3 Complex Macromolecular Substances Receptor-CD3 Complex, Antigen, T-Cell Receptors, Antigen, T-Cell

Authors & Affiliations

1 authors, click to expand affiliations / ORCID

Engelman Donald M

Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT 06511, USA.

Article Info

Journal

Molecular cell

Abbr.

Mol Cell

ISSN

1097-2765

DOI

10.1016/s1097-2765(03)00016-9

Published

2003-01-00

Pages

5-6

Language

English

Region

United States

NLM ID

9802571

Subset

External Links

PubMed source DOI: 10.1016/s1097-2765(03)00016-9 View journal details

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Electrostatic fasteners hold the T cell receptor-CD3 complex together.

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