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题目:: Molecular and functional profiling of memory CD8 T cell differentiation.
作者:: Kaech(Susan M),Hemby(Scott),Kersh(Ellen),Ahmed(Rafi)
状态:: 发布时间2003-01-15 , 更新时间 2007-11-14
期刊:: Cell
摘要:: How and when memory T cells form during an immune response are long-standing questions. To better understand memory CD8 T cell development, a time course of gene expression and functional changes in antigen-specific T cells during viral infection was evaluated. The expression of many genes continued to change after viral clearance in accordance with changes in CD8 T cell functional properties. Even though memory cell precursors were present at the peak of the immune response, these cells did not display hallmark functional traits of memory T cells. However, these cells gradually acquired the memory cell qualities of self-renewal and rapid recall to antigen suggesting the model that antigen-specific CD8 T cells progressively differentiate into memory cells following viral infection.
语言:: eng
DOI:

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