BRCA2 keeps Rad51 in line. High-fidelity homologous recombination prevents breast and ovarian cancer?

Molecular cell ·Vol. 10 ·No. 6 ·2002-12-00 ·Pages 1262-3

Powell SN, Willers H, Xia F

Abstract

The mechanistic link between the BRCA2 protein, homologous recombination, and genomic instability has become clearer as a result of recent work describing the structures of different BRCA2 domains bound to Rad51 and to single-stranded DNA.

MeSH Terms

BRCA2 Protein/genetics Breast Neoplasms/genetics,prevention & control DNA-Binding Proteins/genetics Female Gene Expression Regulation Genes, BRCA2 Humans Models, Genetic Ovarian Neoplasms/genetics,prevention & control Rad51 Recombinase Recombination, Genetic

Chemicals

BRCA2 Protein DNA-Binding Proteins RAD51 protein, human Rad51 Recombinase

Authors & Affiliations

3 authors, click to expand affiliations / ORCID

Powell Simon N

Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, Building 149, 13th Street, Charlestown, MA 02129, USA.

Willers Henning

Xia Fen

Article Info

Journal

Molecular cell

Abbr.

Mol Cell

ISSN

1097-2765

DOI

10.1016/s1097-2765(02)00789-x

Published

2002-12-00

Pages

1262-3

Language

English

Region

United States

NLM ID

9802571

Subset

Corrections

CommentOn

PMID: 11239455

CommentOn

PMID: 11239456

External Links

PubMed source DOI: 10.1016/s1097-2765(02)00789-x View journal details

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BRCA2 keeps Rad51 in line. High-fidelity homologous recombination prevents breast and ovarian cancer?

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