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PMID: 12502528 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. Review

The Na+/Ca2+ exchange molecule: an overview.

Annals of the New York Academy of Sciences ·Vol. 976 ·2002-11-00 ·Pages 1-10

Philipson KD, Nicoll DA, Ottolia M, Quednau BD, Reuter H, John S, Qiu Z

Abstract

An overview of the molecular physiology of the Na(+)/Ca(2+) exchanger is presented. This includes information on the variety of exchangers that have been described and their regulatory properties. Molecular insight is most detailed for the cardiac Na(+)/Ca(2+) exchanger (NCX1). Parts of the NCS1 molecule involved in regulation and ion transport have been elucidated, and initial information on the topology and structure is available.

MeSH Terms

Alternative Splicing Animals Brain/physiology Heart/physiology Kidney/physiology Models, Molecular Organ Specificity Protein Conformation Sodium-Calcium Exchanger/chemistry,genetics,physiology

Chemicals

Sodium-Calcium Exchanger

Authors & Affiliations

7 authors, click to expand affiliations / ORCID

Philipson Kenneth D

Department of Physiology and Cardiovascular Research Laboratory, UCLA School of Medicine, Los Angeles, California 90095, USA. kphilipson@mednet.ucla.edu

Nicoll Debora A

Ottolia Michela

Quednau Beate D

Reuter Hannes

John Scott

Qiu Zhiyong

Article Info

Journal

Annals of the New York Academy of Sciences

Abbr.

Ann N Y Acad Sci

ISSN

0077-8923

DOI

10.1111/j.1749-6632.2002.tb04708.x

kphilipson@mednet.ucla.edu

Published

2002-11-00

Pages

1-10

Language

English

Region

United States

NLM ID

7506858

Subset

External Links

PubMed source DOI: 10.1111/j.1749-6632.2002.tb04708.x View journal details

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