A cytogenetic study of human spontaneous abortions using banding techniques.

Human genetics ·Vol. 31 ·No. 2 ·1976-02-29 ·Pages 177-96

Creasy MR, Crolla JA, Alberman ED

Abstract

The karyotypes of 941 singleton and 42 twin abortuses and 4 cystic placentae were determined. 30.5% of the singletons were chromosomally abnormal; 49.8% of these were trisomic, 23.7% X-monosomics and 17.4% polyploid. 143 trisomies were identified by banding; over a third had an extra chromosome 16, more than 10% an extra 21 or 22 and about 5% an extra 2, 18 or 15. Examples of trisomy 3, 4, 8, 9, 10, 13, 14 and 20 were also encountered. Using the data from two other published studies, the prevalence of different trisomies was estimated and an attempt was made to relate the karyotype of the conceptus to its subsequent development.

MeSH Terms

Abortion, Spontaneous/genetics Adult Aneuploidy Chromosome Aberrations/genetics Chromosome Deletion Chromosome Disorders Congenital Abnormalities/genetics Female Fetal Death/genetics Fetus/cytology Gestational Age Humans Hydatidiform Mole/genetics Male Maternal Age Mosaicism Phenotype Placenta Diseases/genetics Polyploidy Pregnancy Sex Chromosome Aberrations/genetics Sex Ratio Translocation, Genetic Trisomy Twins

Authors & Affiliations

3 authors, click to expand affiliations / ORCID

Creasy M R

Crolla J A

Alberman E D

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21 references, click to expand

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Article Info

Journal

Human genetics

Abbr.

Hum Genet

ISSN

0340-6717

DOI

10.1007/BF00296145

Published

1976-02-29

Pages

177-96

Language

English

Region

Germany

NLM ID

7613873

Subset

External Links

PubMed source DOI: 10.1007/BF00296145 View journal details

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A cytogenetic study of human spontaneous abortions using banding techniques.

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