Different effect of ouabain on the interferon production and action.

Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.) ·Vol. 149 ·No. 1 ·1975-05-00 ·Pages 108-12

Lebon P, Moreau MC, Cohen L, Chany C

Abstract

Ouabain, which inhibits specifically membrane-bound ATPase activity, also inhibits the establishment of the antiviral state induced by interferon. Once the antiviral state is established, ouabain is ineffective. This inhibitory effect is reversed by adding Na/K ions to the cells. On the contrary, interferon production is unaffected by the same concentrations of ouabain. It is of interest that in such interferon-yielding cells, ouabain decreases the antiviral state.

MeSH Terms

Adenosine Triphosphatases/analysis Animals Carbon Radioisotopes Cell Line Connective Tissue Haplorhini Hybrid Cells/metabolism Interferons/antagonists & inhibitors,biosynthesis,metabolism Ion Exchange/drug effects Kidney Mice Ouabain/administration & dosage,pharmacology Potassium/metabolism Protein Biosynthesis Sodium/metabolism Transcription, Genetic/drug effects Tritium Uridine/metabolism

Chemicals

Carbon Radioisotopes Tritium Ouabain Interferons Sodium Adenosine Triphosphatases Potassium Uridine

Authors & Affiliations

4 authors, click to expand affiliations / ORCID

Lebon P

Moreau M C

Cohen L

Chany C

Article Info

Journal

Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.)

Abbr.

Proc Soc Exp Biol Med

ISSN

0037-9727

DOI

10.3181/00379727-149-38753

Published

1975-05-00

Pages

108-12

Language

English

Region

United States

NLM ID

7505892

Subset

External Links

PubMed source DOI: 10.3181/00379727-149-38753 View journal details

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Different effect of ouabain on the interferon production and action.

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