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PMID: 12473340 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. Review

A revised picture of the E2F transcriptional network and RB function.

Current opinion in cell biology ·Vol. 14 ·No. 6 ·2002-12-00 ·Pages 684-91

Stevaux O, Dyson NJ

Abstract

New techniques have enhanced our picture of E2F regulation. These studies have shed light on the roles played by individual E2F and retinoblastoma family members and implicate these proteins in processes extending well beyond the G1/S transition. One thorny issue remains: do our current molecular models of E2F and retinoblastoma action explain all of the functions of these proteins in vivo?

MeSH Terms

Animals Apoptosis Binding Sites Cell Cycle Proteins DNA Damage DNA Repair DNA Replication DNA-Binding Proteins E2F Transcription Factors Gene Expression Regulation, Developmental Mitosis Models, Genetic Promoter Regions, Genetic Retinoblastoma Protein/physiology Transcription Factors/physiology Transcriptional Activation

Chemicals

Cell Cycle Proteins DNA-Binding Proteins E2F Transcription Factors Retinoblastoma Protein Transcription Factors

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Stevaux Olivier

Massachusetts General Hospital Cancer Center, Laboratory of Molecular Oncology, Charlestown, MA 02129, USA.

Dyson Nicholas J

Article Info

Journal

Current opinion in cell biology

Abbr.

Curr Opin Cell Biol

ISSN

0955-0674

DOI

10.1016/s0955-0674(02)00388-5

Published

2002-12-00

Pages

684-91

Language

English

Region

England

NLM ID

8913428

Subset

Grants

NCI NIH HHS · CA64402 · United States

NIGMS NIH HHS · GM53203 · United States

External Links

PubMed source DOI: 10.1016/s0955-0674(02)00388-5 View journal details

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A revised picture of the E2F transcriptional network and RB function.

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