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题目:: Methylenetetrahydrofolate reductase polymorphism and susceptibility to breast cancer.
作者:: Campbell(Ian G),Baxter(Simon W),Eccles(Diana M),Choong(David Y H)
状态:: 发布时间2002-12-10 , 更新时间 2014-06-11
期刊:: Breast Cancer Res
摘要:: A growing body of evidence suggests that variations in the levels of folate may contribute to the development of cancer. A functional polymorphic variant (C-->T substitution at nucleotide 677) in the 5,10-methylenetetrahydrofolate reductase (MTHFR) gene results in the conversion of an alanine to a valine and may modify the risk of breast and other cancers.,We have investigated the possible influence of this MTHFR variant on breast cancer risk in a case-control study of 233 healthy women and 335 women who had breast cancer that occurred under the age of 40 years, bilateral breast cancer or a family history of breast cancer.,A significant excess of the valine genotypes was observed among the cases (odds ratio 1.43, 95% confidence interval 1.02-2.00). The effect was more pronounced among the cases with a breast cancer diagnosis under the age of 40 years, with an odds ratio of 1.66 (95% confidence interval 1.12-2.41). A nonsignificant excess of the valine genotypes was observed among the cases with a family history of breast cancer or bilateral breast cancer.,The low activity C677T (valine) genotype of MTHFR may increase the risk of early onset breast cancer.
语言:: eng
DOI:

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