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PMID: 1246600 Published · ppublish English Comparative Study Journal Article Research Support, U.S. Gov't, Non-P.H.S. Research Support, U.S. Gov't, P.H.S.

Human heart and platelet actins are products of different genes.

Science (New York, N.Y.) ·Vol. 191 ·No. 4222 ·1976-01-09 ·Pages 94-5

Elzinga M, Maron BJ, Adelstein RS

Abstract

The amino acid sequences of selected cyanogen bromide peptides from human blood platelet actin and human cardiac muscle actin were compared; it was found that, at position 129, platelet actin has threonine, and that cardiac muscle actin has valine. Thus human cytoplasmic and myofibrillar actins must be synthesized under the control of different genes.

MeSH Terms

Actins/analysis,biosynthesis,blood Amino Acid Sequence Amino Acids/analysis Blood Platelets/metabolism Cytoplasm/metabolism Genes Humans Myocardium/metabolism Myofibrils/metabolism Peptides/analysis

Chemicals

Actins Amino Acids Peptides

Authors & Affiliations

3 authors, click to expand affiliations / ORCID

Elzinga M

Maron B J

Adelstein R S

Article Info

Journal

Science (New York, N.Y.)

Abbr.

Science

ISSN

0036-8075

DOI

10.1126/science.1246600

Published

1976-01-09

Pages

94-5

Language

English

Region

United States

NLM ID

0404511

Subset

External Links

PubMed source DOI: 10.1126/science.1246600 View journal details

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Human heart and platelet actins are products of different genes.

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