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PMID: 12464424 Published · ppublish English Journal Article Research Support, U.S. Gov't, Non-P.H.S. Research Support, U.S. Gov't, P.H.S.

Host adaptation and host-parasite co-evolution in Cryptosporidium: implications for taxonomy and public health.

International journal for parasitology ·Vol. 32 ·No. 14 ·2002-12-19 ·Pages 1773-85

Xiao L, Sulaiman IM, Ryan UM, Zhou L, Atwill ER, Tischler ML, Zhang X, Fayer R, Lal AA

Abstract

To assess the genetic diversity and evolution of Cryptosporidium parasites, the partial ssrRNA, actin, and 70kDa heat shock protein (HSP70) genes of 15 new Cryptosporidium parasites were sequenced. Sequence data were analysed together with those previously obtained from other Cryptosporidium parasites (10 Cryptosporidium spp. and eight Cryptosporidium genotypes). Results of this multi-locus genetic characterisation indicate that host adaptation is a general phenomenon in the genus Cryptosporidium, because specific genotypes were usually associated with specific groups of animals. On the other hand, host-parasite co-evolution is also common in Cryptosporidium, as closely related hosts usually had related Cryptosporidium parasites. Results of phylogenetic analyses suggest that the Cryptosporidium parvum bovine genotype and Cryptosporidium meleagridis were originally parasites of rodents and mammals, respectively, but have subsequently expanded their host ranges to include humans. Understanding the evolution of Cryptosporidium species is important not only for clarification of the taxonomy of the parasites but also for assessment of the public health significance of Cryptosporidium parasites from animals.

MeSH Terms

Actins/genetics Animals Base Sequence Biological Evolution Cryptosporidium/classification,genetics,physiology DNA, Protozoan/genetics Genes, rRNA/genetics Genetic Variation Genotype HSP70 Heat-Shock Proteins/genetics Host-Parasite Interactions/genetics Humans Molecular Sequence Data Phylogeny Polymerase Chain Reaction/methods Public Health

Chemicals

Actins DNA, Protozoan HSP70 Heat-Shock Proteins

Authors & Affiliations

9 authors, click to expand affiliations / ORCID

Xiao Lihua

Division of Parasitic Diseases, Mail Stop F-12, Centers for Disease Control and Prevention, U.S. PHS/DHHS, 4770 Buford Highway, Atlanta, GA 30341, USA. lax0@cdc.gov

Sulaiman Irshad M

Ryan Una M

Zhou Ling

Atwill Edward R

Tischler Monica L

Zhang Xichen

Fayer Ronald

Lal Altaf A

Article Info

Journal

International journal for parasitology

Abbr.

Int J Parasitol

ISSN

0020-7519

DOI

10.1016/s0020-7519(02)00197-2

lax0@cdc.gov

Published

2002-12-19

Pages

1773-85

Language

English

Region

England

NLM ID

0314024

Subset

Databases

GENBANK

AY120901, AY120902, AY120903, AY120904, AY120905, AY120906, AY120907, AY120908, AY120909, AY120910, AY120911, AY120912, AY120913, AY120914, AY120915, AY120916, AY120917, AY120918, AY120919, AY120920, AY120921, AY120922, AY120923, AY120924, AY120925, AY120926, AY120927, AY120928, AY120929, AY120930, AY120931, AY120932

External Links

PubMed source DOI: 10.1016/s0020-7519(02)00197-2 View journal details

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Host adaptation and host-parasite co-evolution in Cryptosporidium: implications for taxonomy and public health.

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