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PMID: 12461561 Published · ppublish English Research Support, Non-U.S. Gov't Review

How do microtubules guide migrating cells?

Nature reviews. Molecular cell biology ·Vol. 3 ·No. 12 ·2002-00-00 ·Pages 957-64

Small JV, Geiger B, Kaverina I, Bershadsky A

Abstract

Microtubules have long been implicated in the polarization of migrating cells, but how they carry out this role is unclear. Here, we propose that microtubules determine cell polarity by modulating the pattern of adhesions that a cell develops with the underlying matrix, through focal inhibitions of contractility.

MeSH Terms

Actins/metabolism Animals Cell Adhesion/physiology Cell Membrane Structures/metabolism Cell Movement/physiology Cell Polarity Cells, Cultured Cytoskeleton/metabolism Fibroblasts/cytology,metabolism Green Fluorescent Proteins Luminescent Proteins/metabolism Microtubules/metabolism

Chemicals

Actins Luminescent Proteins Green Fluorescent Proteins

Authors & Affiliations

4 authors, click to expand affiliations / ORCID

Small J Victor

Geiger Benjamin

Kaverina Irina

Bershadsky Alexander

Article Info

Journal

Nature reviews. Molecular cell biology

Abbr.

Nat Rev Mol Cell Biol

ISSN

1471-0072

DOI

10.1038/nrm971

Published

2002-00-00

Pages

957-64

Language

English

Region

England

NLM ID

100962782

Subset

External Links

PubMed source DOI: 10.1038/nrm971 View journal details

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How do microtubules guide migrating cells?

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