Home LiteratureArticle Details
PMID: 12453352 Published · ppublish English Journal Article Research Support, U.S. Gov't, Non-P.H.S.

Mycobacterium tuberculosis transmission between cluster members with similar fingerprint patterns.

Emerging infectious diseases ·Vol. 8 ·No. 11 ·2002-11-00 ·Pages 1257-9

Ijaz K, Yang Z, Matthews HS, Bates JH, Cave MD

Abstract

Molecular epidemiologic studies provide evidence of transmission of Mycobacterium tuberculosis within clusters of patients whose isolates share identical IS6110-DNA fingerprint patterns. However, M. tuberculosis transmission among patients whose isolates have similar but not identical DNA fingerprint patterns (i.e., differing by a single band) has not been well documented. We used DNA fingerprinting, combined with conventional epidemiology, to show unsuspected patterns of tuberculosis transmission associated with three public bars in the same city. Among clustered TB cases, DNA fingerprinting analysis of isolates with similar and identical fingerprints helped us discover epidemiologic links missed during routine tuberculosis contact investigations.

MeSH Terms
Adult Arkansas/epidemiology Cluster Analysis Contact Tracing DNA Fingerprinting Humans Molecular Epidemiology Mycobacterium tuberculosis/classification,genetics Risk Factors Tuberculosis/epidemiology,microbiology,transmission
Authors & Affiliations
5 authors, click to expand affiliations / ORCID
Ijaz Kashef
Centers for Disease Control and Prevention, Atlanta, GA 30333, USA.
Yang Zhenhua
Matthews H Stewart
Bates Joseph H
Cave M Donald
References (17)
17 references, click to expand
  1. Evaluation of method for secondary DNA typing of Mycobacterium tuberculosis with pTBN12 in epidemiologic study of tuberculosis.
    J Clin Microbiol. 1996 Dec;34(12):3044-8 PMID: 8940446
  2. Usefulness of the secondary probe pTBN12 in DNA fingerprinting of Mycobacterium tuberculosis.
    J Clin Microbiol. 1996 May;34(5):1118-23 PMID: 8727887
  3. Patterns of tuberculosis transmission in Central Los Angeles.
    JAMA. 1997 Oct 8;278(14):1159-63 PMID: 9326475
  4. Complex transmission dynamics of clonally related virulent Mycobacterium tuberculosis associated with barhopping by predominantly human immunodeficiency virus-positive gay men.
    J Infect Dis. 1999 Oct;180(4):1245-51 PMID: 10479154
  5. Occurrence and stability of insertion sequences in Mycobacterium tuberculosis complex strains: evaluation of an insertion sequence-dependent DNA polymorphism as a tool in the epidemiology of tuberculosis.
    J Clin Microbiol. 1991 Nov;29(11):2578-86 PMID: 1685494
  6. An outbreak of multidrug-resistant tuberculosis among hospitalized patients with the acquired immunodeficiency syndrome.
    N Engl J Med. 1992 Jun 4;326(23):1514-21 PMID: 1304721
  7. Emergence during unsuccessful chemotherapy of multiple drug resistance in a strain of Mycobacterium tuberculosis.
    Eur J Clin Microbiol Infect Dis. 1992 Oct;11(10):901-7 PMID: 1362540
  8. Exogenous reinfection with multidrug-resistant Mycobacterium tuberculosis in patients with advanced HIV infection.
    N Engl J Med. 1993 Apr 22;328(16):1137-44 PMID: 8096066
  9. Characterization of Mycobacterium tuberculosis strains from Vietnamese patients by Southern blot hybridization.
    J Clin Microbiol. 1993 Jun;31(6):1615-8 PMID: 8100244
  10. Comparison of various repetitive DNA elements as genetic markers for strain differentiation and epidemiology of Mycobacterium tuberculosis.
    J Clin Microbiol. 1993 Aug;31(8):1987-95 PMID: 7690367
  11. Restriction fragment length polymorphism analysis detecting a community-based tuberculosis outbreak among persons infected with human immunodeficiency virus.
    J Infect Dis. 1994 Jan;169(1):189-92 PMID: 7903974
  12. Stability of DNA fingerprint pattern produced with IS6110 in strains of Mycobacterium tuberculosis.
    J Clin Microbiol. 1994 Jan;32(1):262-6 PMID: 7907344
  13. The epidemiology of tuberculosis in San Francisco. A population-based study using conventional and molecular methods.
    N Engl J Med. 1994 Jun 16;330(24):1703-9 PMID: 7910661
  14. A preventable outbreak of tuberculosis investigated through an intricate social network.
    Clin Infect Dis. 2001 Dec 1;33(11):1801-6 PMID: 11692291
  15. Transmission of tuberculosis in New York City. An analysis by DNA fingerprinting and conventional epidemiologic methods.
    N Engl J Med. 1994 Jun 16;330(24):1710-6 PMID: 7993412
  16. Outbreak of tuberculosis among regular patrons of a neighborhood bar.
    N Engl J Med. 1995 Jul 27;333(4):222-7 PMID: 7791838
  17. DNA fingerprinting with two probes decreases clustering of Mycobacterium tuberculosis.
    Am J Respir Crit Care Med. 1997 Mar;155(3):1140-6 PMID: 9117000
Article Info
Journal
Emerging infectious diseases
Abbr.
Emerg Infect Dis
ISSN
1080-6040
DOI
10.3201/eid0811.020284
Published
2002-11-00
Pages
1257-9
Language
English
Region
United States
NLM ID
9508155
PMCID
PMC2738543
Subset
IM
External Links
PubMed source DOI: 10.3201/eid0811.020284 PMC Full Text View journal details
Analysis Services
Analysis Services

Contact

No. 2 Wenbo Road, Zhangqiu District, Jinan, Shandong

Qilu Normal University · Genelibs Bioinformatics Lab

750 Shunhua Rd, Jinan

2F, Bldg F, University Science Park

Tel: 0531-88819269

WeChat Official Account

Follow our WeChat subscription account for real-time updates and the latest in medical and biological research.


Business Email

E-mail: product@genelibs.com

Copyright © 2026.Genelibs Jinan Honghui Biotechnology Co., Ltd. 鲁ICP备20007159号-2