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PMID: 12441113 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Fast and slow intermediate accumulation and the initial barrier mechanism in protein folding.

Journal of molecular biology ·Vol. 324 ·No. 2 ·2002-11-22 ·Pages 359-71

Krantz BA, Mayne L, Rumbley J, Englander SW, Sosnick TR

Abstract

Do stable intermediates form very early in the protein folding process? New results and a quantity of literature that bear on this issue are examined here. Results available provide little support for early intermediate accumulation before an initial search-dependent nucleation barrier.

MeSH Terms

Animals Bacterial Proteins Cytochrome c Group/chemistry Guanidine/pharmacology Heart Horses Kinetics Models, Chemical Models, Molecular Nerve Tissue Proteins/chemistry Protein Conformation Protein Denaturation Protein Folding Ribonuclease, Pancreatic/chemistry Ribonucleases/chemistry Thermodynamics Time Factors Ubiquitin/chemistry

Chemicals

Bacterial Proteins Cytochrome c Group G-substrate Nerve Tissue Proteins Ubiquitin Ribonucleases Bacillus amyloliquefaciens ribonuclease Ribonuclease, Pancreatic Guanidine

Authors & Affiliations

5 authors, click to expand affiliations / ORCID

Krantz Bryan A

Department of Biochemistry and Molecular Biology, University of Chicago, Chicago, IL 60637, USA.

Mayne Leland

Rumbley Jon

Englander S Walter

Sosnick Tobin R

Article Info

Journal

Journal of molecular biology

Abbr.

J Mol Biol

ISSN

0022-2836

DOI

10.1016/s0022-2836(02)01029-x

Published

2002-11-22

Pages

359-71

Language

English

Region

England

NLM ID

2985088R

Subset

External Links

PubMed source DOI: 10.1016/s0022-2836(02)01029-x View journal details

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