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题目:: Frameshift mutations in the MBD4/MED1 gene in primary gastric cancer with high-frequency microsatellite instability.
作者:: Yamada(Tatsuya),Koyama(Toru),Ohwada(Susumu),Tago(Ken-ichi),Sakamoto(Ichiro),Yoshimura(Sumihiko),Hamada(Kunihiro),Takeyoshi(Izumi),Morishita(Yasuo)
状态:: 发布时间2002-11-14 , 更新时间 2006-11-15
期刊:: Cancer Lett
摘要:: MBD4/MED1 is a newly identified mismatch repair gene, which is mutated in colon, endometrial, and pancreatic high-frequency microsatellite instability (MSI-H) tumors. To assess its role in gastric cancers, we investigated MBD4/MED1 mutations in sporadic gastric cancers, compared with colon cancers. Frameshift mutations were found in 29% of gastric and 20% of colon MSI-H cancers, but not in any low-frequency microsatellite instability/microsatellite stable cancers. MBD4/MED1 is mutated in gastric cancers as frequently as in colon cancers; these mutations reduce the accuracy of DNA repair, and may lead to cancer progression.
语言:: eng
DOI:

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