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题目:: Establishment of a triploid V79 cell line from tetraploid cells obtained through polyploidization using K-252a.
作者:: Fujikawa-Yamamoto(Kohzaburo),Yamagishi(Hiroko),Miyagoshi(Minoru)
状态:: 发布时间2002-11-12 , 更新时间 2011-11-17
期刊:: Cell Prolif
摘要:: Triploid V79 cells were established from tetraploid cells. Diploid V79 cells were polyploidized by K-252a, an inhibitor of protein kinases, and then released from the drug for 10 days. At that time, the cell population was a mixture of diploid and tetraploid cells. Triploid cells were obtained through the cloning of tetraploid cells. They had 33 chromosomes (1.5 times the diploid number) and showed a karyotype of three homologueous chromosomes. The duration of the G1, S and G2/M phases was almost the same as for diploid cells. The cell volume of triploid V79 cells was about two times that of the diploid cells. An explanation for the diploid-tetraploid-triploid transition is proposed.
语言:: eng
DOI:

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