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PMID: 12412741 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Altered IgG-subclass distribution in lymph node cells and serum of adults infected with human immunodeficiency virus (HIV).

Clinical and experimental immunology ·Vol. 78 ·No. 2 ·1989-11-00 ·Pages 153-8

Müller F, Frøland SS, Brandtzaeg P

Abstract

The relative distribution of cells producing subclasses of IgG or IgA was examined by immunohistochemistry in lymph node biopsy specimens from 15 adults with persistent generalized lymphadenopathy due to infection with HIV and from 11 adults with lymph nodes enlarged from other causes. The IgG1 immunocyte fraction was significantly higher and the IgG2 fraction significantly lower associated with HIV infection than in the controls. The proportions of cells producing IgG3, IgG4, IgA I or IgA2 were similar in the two lymph node categories. The altered IgG-subclass distribution of immunocytes in HIV lymphadenopathy concorded with the serum levels that were significantly elevated for IgG1 and lowered for IgG2 compared with a panel of blood donor samples.

MeSH Terms
Adolescent Adult Dendritic Cells, Follicular/immunology,pathology Female HIV Infections/immunology,pathology Humans Immunoglobulin A/blood,classification,metabolism Immunoglobulin G/blood,classification,metabolism Lymph Nodes/immunology,pathology Male
Chemicals
Immunoglobulin A Immunoglobulin G
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Müller F
Laboratory for Immunohistochemistry and Immunopathology, Institute of Pathology, University of Oslo, The National Hospital, Rikshospitalet, Norway.
Frøland S S
Brandtzaeg P
References (33)
33 references, click to expand
  1. Serum IgD elevation is an early marker of B cell activation during infection with the human immunodeficiency viruses.
    Clin Exp Immunol. 1987 Apr;68(1):5-14 PMID: 3498566
  2. Distribution of mucosal IgA and IgG subclass-producing immunocytes and alterations in various disorders.
    Monogr Allergy. 1986;20:179-94 PMID: 3773909
  3. Reduced production of interleukin 2 and interferon-gamma and enhanced helper activity for IgG synthesis by cloned CD4+ T cells from patients with AIDS.
    Eur J Immunol. 1987 Dec;17(12):1685-90 PMID: 2961571
  4. Hypergammaglobulinemia associated with human immunodeficiency virus infection.
    Monogr Allergy. 1988;23:83-96 PMID: 3260340
  5. Human immunodeficiency virus associated changes in germinal centers of lymph nodes and relevance to impaired B-cell function.
    Lymphology. 1988 Mar;21(1):36-43 PMID: 3294513
  6. Comparative immunogenicity of plasma and recombinant hepatitis B virus vaccines in homosexual men.
    JAMA. 1988 Dec 23-30;260(24):3635-7 PMID: 2973531
  7. Induction of IL-6 (B cell stimulatory factor-2/IFN-beta 2) production by HIV.
    J Immunol. 1989 Jan 15;142(2):531-6 PMID: 2783441
  8. Mucosal and glandular distribution of immunoglobulin components. Immunohistochemistry with a cold ethanol-fixation technique.
    Immunology. 1974 Jun;26(6):1101-14 PMID: 4604796
  9. The maintenance and regulation of the humoral immune response: persisting antigen and the role of follicular antigen-binding dendritic cells as accessory cells.
    Immunol Rev. 1980;53:175-201 PMID: 7009404
  10. Pneumocystis carinii pneumonia and mucosal candidiasis in previously healthy homosexual men: evidence of a new acquired cellular immunodeficiency.
    N Engl J Med. 1981 Dec 10;305(24):1425-31 PMID: 6272109
  11. Prolonged incubation time in immunohistochemistry: effects on fluorescence staining of immunoglobulins and epithelial components in ethanol- and formaldehyde-fixed paraffin-embedded tissues.
    J Histochem Cytochem. 1981 Nov;29(11):1302-15 PMID: 7033362
  12. T cell-derived B cell differentiation factor(s). Effect on the isotype switch of murine B cells.
    J Exp Med. 1982 Mar 1;155(3):734-48 PMID: 7038025
  13. Disseminated Kaposi's sarcoma in homosexual men.
    Ann Intern Med. 1982 Jun;96(6 Pt 1):693-700 PMID: 6283973
  14. Immunologic abnormalities in homosexual men. Relationship to Kaposi's sarcoma.
    Am J Med. 1982 Aug;73(2):171-8 PMID: 7114072
  15. Abnormalities of B-cell activation and immunoregulation in patients with the acquired immunodeficiency syndrome.
    N Engl J Med. 1983 Aug 25;309(8):453-8 PMID: 6224088
  16. Generalized lymphadenopathy in homosexual men.
    Ann Intern Med. 1983 Nov;99(5):585-91 PMID: 6605701
  17. B-cell immunodeficiency in acquired immune deficiency syndrome.
    JAMA. 1984 Mar 16;251(11):1447-9 PMID: 6608011
  18. Follicular dendritic cells and virus-like particles in AIDS-related lymphadenopathy.
    Lancet. 1984 Aug 18;2(8399):370-2 PMID: 6147453
  19. Defective B-lymphocyte function in homosexual men in relation to the acquired immunodeficiency syndrome.
    Ann Intern Med. 1984 Dec;101(6):757-63 PMID: 6388451
  20. Serum immunoglobulin elevations in the acquired immunodeficiency syndrome (AIDS): IgG, IgA, IgM, and IgD.
    Diagn Immunol. 1984;2(3):148-53 PMID: 6499376
  21. Altered follicular dendritic cells and virus-like particles in AIDS and AIDS-related lymphadenopathy.
    Lancet. 1985 Jan 12;1(8420):105-6 PMID: 2857002
  22. Immunologic abnormalities in the acquired immunodeficiency syndrome (AIDS).
    Clin Res. 1984 Dec;32(5):491-9 PMID: 6097390
  23. Circulating and mesangial secretory component-binding IgA-1 in primary IgA nephropathy.
    Kidney Int. 1984 Nov;26(5):760-6 PMID: 6441067
  24. An immunohistological approach to persistent lymphadenopathy and its relevance to AIDS.
    Clin Exp Immunol. 1985 Feb;59(2):257-66 PMID: 3884195
  25. Evaluation of monoclonal antibodies having specificity for human IgG sub-classes: results of an IUIS/WHO collaborative study.
    Immunol Lett. 1985;10(3-4):223-52 PMID: 3899923
  26. Influence of the human T-lymphotropic virus/lymphadenopathy-associated virus on functions of human lymphocytes: evidence for immunosuppressive effects and polyclonal B-cell activation by banded viral preparations.
    Proc Natl Acad Sci U S A. 1985 Dec;82(23):8198-202 PMID: 2999797
  27. Cloning of cDNA encoding the murine IgG1 induction factor by a novel strategy using SP6 promoter.
    Nature. 1986 Feb 20-26;319(6055):640-6 PMID: 3005865
  28. Serum immunoglobulin G subclass dysbalances in the lymphadenopathy syndrome and acquired immune deficiency syndrome.
    Clin Exp Immunol. 1986 Jan;63(1):234-40 PMID: 3955884
  29. Dendritic reticulum cells in reactive lymph nodes and tonsils: an immunohistological study.
    Histopathology. 1986 Jan;10(1):15-24 PMID: 3514411
  30. Different subclass distribution of IgA-producing cells in human lymphoid organs and various secretory tissues.
    J Immunol. 1986 May 15;136(10):3631-5 PMID: 3517160
  31. Mechanisms of B cell activation in patients with acquired immunodeficiency syndrome and related disorders. Contribution of antibody-producing B cells, of Epstein-Barr virus-infected B cells, and of immunoglobulin production induced by human T cell lymphotropic virus, type III/lymphadenopathy-associated virus.
    J Clin Invest. 1986 Aug;78(2):439-47 PMID: 3016028
  32. Direct polyclonal activation of human B lymphocytes by the acquired immune deficiency syndrome virus.
    Science. 1986 Sep 5;233(4768):1084-6 PMID: 3016902
  33. Human immunoglobulin subclasses.
    Diagn Clin Immunol. 1987;5(3):115-28 PMID: 3319279
Article Info
Journal
Clinical and experimental immunology
Abbr.
Clin Exp Immunol
ISSN
0009-9104
Published
1989-11-00
Pages
153-8
Language
English
Region
England
NLM ID
0057202
PMCID
PMC1534678
Subset
IM
External Links
PubMed source PMC Full Text View journal details
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