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PMID: 12403079 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S. Review

The role of leptin in the control of body weight.

Nutrition reviews ·Vol. 60 ·No. 10 Pt 2 ·2002-10-00 ·Pages S15-9; discussion S68-84, 85-7

Leibel RL

Abstract

Physiologic responses to high and low leptin concentrations are strikingly asymmetrical. High concentrations often produce minimal effects, whereas low concentrations provoke strong counterregulatory responses. A model and rationale for the physiology is presented.

MeSH Terms
Animals Body Weight/physiology Energy Metabolism/physiology Female Humans Leptin/physiology Male Mice Obesity/physiopathology
Chemicals
Leptin
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
Leibel Rudolph L
Department of Pediatrics, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA.
Article Info
Journal
Nutrition reviews
Abbr.
Nutr Rev
ISSN
0029-6643
DOI
10.1301/002966402320634788
Published
2002-10-00
Pages
S15-9; discussion S68-84, 85-7
Language
English
Region
United States
NLM ID
0376405
Subset
IM
Grants
NIDDK NIH HHS · DK30583 · United States
NIDDK NIH HHS · DK52431 · United States
External Links
PubMed source DOI: 10.1301/002966402320634788 View journal details
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