Evans blue: a specific inhibitor of factor VIII-induced platelet agglutination.

Thrombosis et diathesis haemorrhagica ·Vol. 34 ·No. 3 ·1975-12-15 ·Pages 770-9

Kirby EP

Abstract

Low concentrations of Evans Blue (less than 1 muM) inhibit the agglutination of formalin-treated platelets by bovine Factor VIII or by human Factor VIII in the presence of the antibiotic ristocetin. Evans Blue is a specific inhibitor of this reaction and acts by inhibiting the binding of Factor VIII to the platelet surface.

MeSH Terms

Adenosine Diphosphate/pharmacology Animals Azo Compounds/pharmacology Cattle Collagen/pharmacology Evans Blue/pharmacology Factor VIII/antagonists & inhibitors Humans Lectins/pharmacology Platelet Aggregation/drug effects Polylysine/pharmacology Protein Binding/drug effects Ristocetin Thrombin

Chemicals

Azo Compounds Lectins Ristocetin Polylysine Evans Blue Adenosine Diphosphate Factor VIII Collagen Thrombin

Authors & Affiliations

1 authors, click to expand affiliations / ORCID

Kirby E P

Article Info

Journal

Thrombosis et diathesis haemorrhagica

Abbr.

Thromb Diath Haemorrh

ISSN

0340-5338

Published

1975-12-15

Pages

770-9

Language

English

Region

Germany

NLM ID

7608420

Subset

External Links

PubMed source

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Evans blue: a specific inhibitor of factor VIII-induced platelet agglutination.

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