| GeneLibs

题目:: Increased incidence of ERBB2 overexpression and TP53 mutation in inflammatory breast cancer.
作者:: Turpin(Elizabeth),Bièche(Ivan),Bertheau(Philippe),Plassa(Louis-François),Lerebours(Florence),de Roquancourt(Anne),Olivi(Martine),Espié(Marc),Marty(Michel),Lidereau(Rosette),Vidaud(Michel),de Thé(Hughes)
状态:: 发布时间2002-10-18 , 更新时间 2006-11-15
期刊:: Oncogene
摘要:: Inflammatory breast cancer (IBC) is one of the most aggressive forms of breast cancer. We studied the biological characteristics of these tumours by comparing the overexpression of oncogenes ERBB2, MYC, CCND1 and RHOC and TP53 gene mutation rates in IBC with those found in locally advanced and not otherwise specified breast cancers. The prevalence of the TP53 mutation was much higher in IBC than in the two other types of cancer (57% vs 30). Unexpectedly, however, in IBC tumours, histological grade was independent of TP53 status. In addition, ERBB2 overexpression was twice as frequent in inflammatory as in non-inflammatory tumours, whereas the frequencies of MYC, CCND1 and RHOC overexpression did not vary significantly among the three types of breast cancer. These findings suggest that IBC tumours constitute a distinct subset with a specific pathogenesis. Given the importance of TP53 and ERBB2 in the response to treatments, our observations have important therapeutic implications for the clinical management of IBC patients.
语言:: eng
DOI:: 10.1038/sj.onc.1205932

文献库文献相关信息

DataTable pData

联系方式

微信公众号

文献库 文献相关信息

DataTable pData

联系方式

微信公众号

文献库文献相关信息