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PMID: 12384571 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Expanding protein universe and its origin from the biological Big Bang.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 99 ·No. 22 ·2002-10-29 ·Pages 14132-6

Dokholyan NV, Shakhnovich B, Shakhnovich EI

Abstract

The bottom-up approach to understanding the evolution of organisms is by studying molecular evolution. With the large number of protein structures identified in the past decades, we have discovered peculiar patterns that nature imprints on protein structural space in the course of evolution. In particular, we have discovered that the universe of protein structures is organized hierarchically into a scale-free network. By understanding the cause of these patterns, we attempt to glance at the very origin of life.

MeSH Terms
Computer Simulation Evolution, Molecular Models, Molecular Protein Structure, Tertiary Proteins/chemistry
Chemicals
Proteins
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Dokholyan Nikolay V
Department of Chemistry and Chemical Biology, Harvard University, 12 Oxford Street, Cambridge, MA 02138, USA. dokh@med.unc.edu
Shakhnovich Boris
Shakhnovich Eugene I
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Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.202497999
Email
dokh@med.unc.edu
Published
2002-10-29
Epub
2002-00-16
Pages
14132-6
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC137849
Subset
IM
Grants
NIGMS NIH HHS · R01 GM052126 · United States
NIGMS NIH HHS · GM52126 · United States
NIGMS NIH HHS · GM20251 · United States
NIGMS NIH HHS · R56 GM052126 · United States
NIGMS NIH HHS · F32 GM020251 · United States
External Links
PubMed source DOI: 10.1073/pnas.202497999 PMC Full Text View journal details
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