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PMID: 12383196 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Review

CD20-mediated apoptosis: signalling through lipid rafts.

Immunology ·Vol. 107 ·No. 2 ·2002-10-00 ·Pages 176-82

Deans JP, Li H, Polyak MJ

Abstract

CD20 is an effective target for therapeutic B-cell depletion with monoclonal antibodies. One proposed mechanism of action is direct cytotoxicity mediated via tyrosine kinase-dependent signalling pathways activated upon CD20 cross-linking. The association of CD20 with membrane microdomains known as lipid rafts, enriched in src-family tyrosine kinases and other signalling effectors, suggests an indirect mechanism of anti-CD20-induced apoptosis in which activation of src-family kinases occurs as a consequence of lipid raft clustering.

MeSH Terms
Amino Acid Sequence Animals Antigens, CD20/genetics,immunology Apoptosis/immunology Humans Membrane Microdomains/immunology Molecular Sequence Data Signal Transduction/immunology
Chemicals
Antigens, CD20
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Deans Julie P
Immunology Research Group, Department of Biochemistry and Molecular Biology, University of Calgary, 3330 Hospital Drive NW, Calgary, Alberta, Canada T2N 4N1. jdeans@ucalgary.ca
Li Haidong
Polyak Maria J
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Article Info
Journal
Immunology
Abbr.
Immunology
ISSN
0019-2805
DOI
10.1046/j.1365-2567.2002.01495.x
Email
jdeans@ucalgary.ca
Published
2002-10-00
Pages
176-82
Language
English
Region
England
NLM ID
0374672
PMCID
PMC1782791
Subset
IM
External Links
PubMed source DOI: 10.1046/j.1365-2567.2002.01495.x PMC Full Text View journal details
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