Identification of TOR signaling complexes: more TORC for the cell growth engine.

Cell ·Vol. 111 ·No. 1 ·2002-10-04 ·Pages 9-12

Abraham RT

Abstract

The Target of Rapamycin (TOR) proteins function in signaling pathways that promote protein synthesis and cell growth. In yeast, TOR signaling is regulated by nutrient availability, whereas in metazoan cells TOR activities may be controlled by both nutrients and growth factors. The recent identification of novel TOR-interacting proteins has provided crucial insights into TOR regulation and function.

MeSH Terms

Animals Cell Cycle Proteins Cell Division Drosophila Fungal Proteins/chemistry,metabolism Humans Models, Biological Phenotype Phosphatidylinositol 3-Kinases/classification Phosphotransferases (Alcohol Group Acceptor)/chemistry,metabolism Protein Structure, Tertiary Saccharomyces cerevisiae/metabolism Saccharomyces cerevisiae Proteins Signal Transduction Sirolimus/pharmacology

Chemicals

Cell Cycle Proteins Fungal Proteins Saccharomyces cerevisiae Proteins Phosphotransferases (Alcohol Group Acceptor) TOR1 protein, S cerevisiae TOR2 protein, S cerevisiae Sirolimus

Authors & Affiliations

1 authors, click to expand affiliations / ORCID

Abraham Robert T

Program in Signal Transduction Research, Cancer Research Center, The Burnham Institute, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA. abraham@burnham.org

Article Info

Journal

Cell

Abbr.

Cell

ISSN

0092-8674

DOI

10.1016/s0092-8674(02)01009-7

abraham@burnham.org

Published

2002-10-04

Pages

9-12

Language

English

Region

United States

NLM ID

0413066

Subset

External Links

PubMed source DOI: 10.1016/s0092-8674(02)01009-7 View journal details

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Identification of TOR signaling complexes: more TORC for the cell growth engine.

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