Microtubule capture: IQGAP and CLIP-170 expand the repertoire.

Current biology : CB ·Vol. 12 ·No. 19 ·2002-10-01 ·Pages R645-7

Gundersen GG

Abstract

Rho GTPases regulate microtubule capture near the cell cortex to polarize cells. What is surprising is the repertoire of interactions between proteins at the ends of microtubules and their cortical targets. The microtubule tip protein CLIP-170 has now been found to interact with the Cdc42/Rac effector IQGAP and mediate transient capture of microtubules.

MeSH Terms

Microfilament Proteins/metabolism Microtubule-Associated Proteins/metabolism Microtubules/chemistry,metabolism Neoplasm Proteins ras GTPase-Activating Proteins rho GTP-Binding Proteins/metabolism

Chemicals

IQ motif containing GTPase activating protein 1 Microfilament Proteins Microtubule-Associated Proteins Neoplasm Proteins ras GTPase-Activating Proteins cytoplasmic linker protein 170 rho GTP-Binding Proteins

Authors & Affiliations

1 authors, click to expand affiliations / ORCID

Gundersen Gregg G

Department of Anatomy & Cell Biology, Columbia University, New York, NY 10032, USA. ggg1@columbia.edu

Article Info

Journal

Current biology : CB

Abbr.

Curr Biol

ISSN

0960-9822

DOI

10.1016/s0960-9822(02)01156-9

ggg1@columbia.edu

Published

2002-10-01

Pages

R645-7

Language

English

Region

England

NLM ID

9107782

Subset

External Links

PubMed source DOI: 10.1016/s0960-9822(02)01156-9 View journal details

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Microtubule capture: IQGAP and CLIP-170 expand the repertoire.

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