Changes in drug metabolism with increasing age: 2. phenytoin clearance and protein binding.

British journal of clinical pharmacology ·Vol. 2 ·No. 1 ·1975-02-00 ·Pages 73-9

Hayes MJ, Langman MJ, Short AH

Abstract

1 Comparison of phenytoin clearance showed a marked increase in people over 65 years of age compared with people under 45 years of age. 2 This difference was apparent if phenytoin was given orally or intravenously. 3 Phenytoin clearance correlated inversely with phenytoin binding and plasma albumin, both of which were found to be reduced in the elderly.

MeSH Terms

Adult Aged Aging Female Humans Male Metabolic Clearance Rate/drug effects Phenobarbital/pharmacology Phenytoin/metabolism Protein Binding Serum Albumin/analysis,metabolism

Chemicals

Serum Albumin Phenytoin Phenobarbital

Authors & Affiliations

3 authors, click to expand affiliations / ORCID

Hayes M J

Langman M J

Short A H

References (10)

10 references, click to expand

Effect of age and sex on human drug metabolism.
Br Med J. 1971 Sep 11;3(5775):607-9 PMID: 5569980
Serum protein binding of thyroxine and diphenylhydantoin.
J Clin Endocrinol Metab. 1966 Mar;26(3):305-8 PMID: 4159984
The metabolic fate of diphenylhydantoin in the dog, rat and man.
J Pharmacol Exp Ther. 1960 Nov;130:275-84 PMID: 13768600
A graphic method for the determination and presentation of binding parameters in a complex system.
Anal Biochem. 1967 Sep;20(3):525-32 PMID: 6048188
The determination of human serum albumin by its specific binding of the anionic dye, 2-(4'-hydroxybenzeneazo)-benzoic acid.
Clin Chim Acta. 1965 Nov;12(5):532-41 PMID: 5865888
Rapid determination of diphenylhydantoin in blood plasma by gas-liquid chromatography.
Anal Chem. 1970 Mar;42(3):421-2 PMID: 5415415
The rate of decline of diphenylhydantoin in human plasma.
Clin Pharmacol Ther. 1970 Jan-Feb;11(1):121-34 PMID: 5410894
Plasma protein binding of diphenylhydantoin in man. Interaction with other drugs and the effect of temperature and plasma dilution.
Clin Pharmacol Ther. 1970 Nov-Dec;11(6):846-55 PMID: 4394754
Protein measurement with the Folin phenol reagent.
J Biol Chem. 1951 Nov;193(1):265-75 PMID: 14907713
Studies on the coumarin anticoagulant drugs: interaction of human plasma albumin and warfarin sodium.
J Clin Invest. 1967 May;46(5):829-37 PMID: 6025484

Article Info

Journal

British journal of clinical pharmacology

Abbr.

Br J Clin Pharmacol

ISSN

0306-5251

DOI

10.1111/j.1365-2125.1975.tb00475.x

Published

1975-02-00

Pages

73-9

Language

English

Region

England

NLM ID

7503323

PMCID

PMC1402501

Subset

External Links

PubMed source DOI: 10.1111/j.1365-2125.1975.tb00475.x PMC Full Text View journal details

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Changes in drug metabolism with increasing age: 2. phenytoin clearance and protein binding.

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