Pharmacokinetics of a single dose of phenytoin in man measured by radioimmunoassay.

British journal of clinical pharmacology ·Vol. 2 ·No. 4 ·1975-08-00 ·Pages 345-9

Robinson JD, Morris BA, Aherne GW, Marks V

Abstract

1. Serum concentrations of phenytoin were studied by radioimmunoassay in five normal volunteers following a single oral dose of phenytoin sodium (100 mg). 2. Two distinct peaks were found at 2.5-3.5 and 10-12 h after ingestion. Maximum serum concentrations ranged from 1.56 mug/ml. The mean plasma half-life of the drug under these conditions was 9.81 +/- 0.66 (s.e. mean) hours.

MeSH Terms

Administration, Oral Adult Half-Life Humans Kinetics Phenytoin/administration & dosage,blood Radioimmunoassay/methods

Chemicals

Phenytoin

Authors & Affiliations

4 authors, click to expand affiliations / ORCID

Robinson J D

Morris B A

Aherne G W

Marks V

References (11)

11 references, click to expand

Anticonvulsant drugs. I. Patho-physiological and pharmacological aspects.
Drugs. 1972;4(3):227-55 PMID: 4405017
Radioimmunoassay and saturation analysis. Pharmacology.
Br Med Bull. 1974 Jan;30(1):80-6 PMID: 4468056
Antiserum to diphenylhydantoin: preparation and characterization.
Res Commun Chem Pathol Pharmacol. 1973 May;5(3):767-74 PMID: 4701269
A rapid micro-method for determining four anti-convulsant drugs by gas-liquid chromatography.
Clin Chim Acta. 1973 Oct 12;48(2):135-41 PMID: 4796630
Pharmacokinetics of single and multiple doses of phenytoin in man.
Eur J Clin Pharmacol. 1974;7(2):81-6 PMID: 4853604
Metabolic disposition of diphenylhydantoin in normal human subjects following intravenous administration.
Clin Pharmacol Ther. 1969 Jul-Aug;10(4):498-504 PMID: 5793754
Development of a radioimmunoassay for etorphine (preliminary communication).
Res Commun Chem Pathol Pharmacol. 1975 Jan;10(1):1-8 PMID: 1168361
Measurement of therapeutic agents in blood.
Adv Clin Chem. 1973;16:47-109 PMID: 4589494
A radioimmunoassay for diphenylhydantoin.
Clin Chim Acta. 1973 Jan 24;43(2):231-41 PMID: 4734567
The rate of decline of diphenylhydantoin in human plasma.
Clin Pharmacol Ther. 1970 Jan-Feb;11(1):121-34 PMID: 5410894
Clinical and electroencephalographic correlations with serum levels of diphenylhydanotin.
Arch Neurol. 1960 Jun;2:624-30 PMID: 13805571

Article Info

Journal

British journal of clinical pharmacology

Abbr.

Br J Clin Pharmacol

ISSN

0306-5251

DOI

10.1111/j.1365-2125.1975.tb02782.x

Published

1975-08-00

Pages

345-9

Language

English

Region

England

NLM ID

7503323

PMCID

PMC1402591

Subset

External Links

PubMed source DOI: 10.1111/j.1365-2125.1975.tb02782.x PMC Full Text View journal details

Analysis Services

Pharmacokinetics of a single dose of phenytoin in man measured by radioimmunoassay.

Contact

WeChat Official Account