Survey of a Scottish diabetic clinic: a study of the etiology of diabetes mellitus.

The Journal of clinical endocrinology ·Vol. 9 ·No. 1 ·1949-01-00 ·Pages 48-78

Munro HN, Eaton JC, Glen A

Abstract

暂无摘要

Keywords

Age Factors Anthropometry Biology Blood Pressure Body Weight Cerebrovascular Effects Demographic Factors Developed Countries Diabetes Mellitus--etiology Diseases Economic Factors Endocrine Effects Endocrine System Europe Fertility Fertility Measurements Genetics Hemic System Hypertension Information Information Processing Macroeconomic Factors Marital Status Measurement Mortality Northern Europe Nuptiality Parity Physiology Population Population Characteristics Population Dynamics Records Research Methodology Scotland Sex Factors Socioeconomic Factors United Kingdom Vascular Diseases

MeSH Terms

Age Factors Anthropometry Biology Birth Rate Blood Blood Pressure Body Weight Cerebrovascular Circulation Demography Developed Countries Diabetes Mellitus Disease Economics Electronic Data Processing Endocrine Glands Endocrine System Europe Fertility Genetics Hypertension Marital Status Marriage Mortality Parity Physiology Population Population Characteristics Population Dynamics Records Research Research Design Scotland Sex Factors Socioeconomic Factors United Kingdom Vascular Diseases

Authors & Affiliations

3 authors, click to expand affiliations / ORCID

Munro H N

Eaton J C

Glen A

Other Abstracts

eng

Certain features of a group of 1309 diabetics were studied. The group was considered representative of Scottish diabetics since the sex distribution of cases corresponded to the sex distribution of deaths from diabetes recorded in the official mortality statistics for Scotland. Evidence is presented which justifies the use of Scottish mortality statistics for this purpose. A study of the incidence of diabetes in 413,110 Scottish recruits (male and female) suggested that in the general population the sex distribution of persons with undiagnosed diabetes might not be the same as that of persons known to have the disease. In both sexes, the disease began most frequently after age 40

sex incidence was equal up to age 40 and thereafter, female diabetics were more common than male diabetics. The high frequency of diabetes in women of middle age was confined to married women and appeared to be related, at least in part, to previous childbearing. The age at onset and the severity of the disease in this group of women were apparently uninfluenced by marriage and childbearing. Adult diabetics were no taller than the controls (hospital visitors). In the case of women diabetics, the maximum weight was significantly greater than that of the control from age 20 onwards, and in the case of male diabetics, from age 40 onwards. In both groups, married women were heavier than single women. The mean blood pressure was significantly higher in female diabetics after age 30 than in the corresponding control group. This hypertension could not be adequately explained on the grounds of obesity

it was not related to previous childbearing. Of 923 diabetics questioned, 23.2% had a family history of diabetes. As age at onset of the disease increased, positive family histories decreased. There was no relationship between presence of a positive family history and severity of the disease. The frequency of a positive family history in obese and hypertensive patients did not differ from that of a group of diabetics as a whole. In the group of middle aged married women, those with the largest families gave the fewest positive family histories. It was considered that there was no proof of parital sex linkage of the hereditary factor, and no convincing evidence that age at onset is determined by heredity. Thyrotoxicosis was present in 1% of the cases. Age at onset in these cases was similar to that of diabetics in general. Sepsis was associated with onset of diabetes in 6% of the cases, but average age at onset was that of diabetics in general and a family history of diabetes was obtained in 18% of the cases. After examining these data, it was concluded that etiologic factors in human diabetes could be divided into hereditary factor(s) fundamental to almost all cases or factors increasing the susceptibility of those persons predisposed to diabetes by a hereditary factor such as abesity, factor(s) associated with childbearing, and minor factors such as sepsis, thyrotoxicosis, or acromegaly.

Article Info

Journal

The Journal of clinical endocrinology

Abbr.

J Clin Endocrinol

ISSN

0368-1610

Published

1949-01-00

Pages

48-78

Language

English

Region

United States

NLM ID

17840150R

External Links

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Survey of a Scottish diabetic clinic: a study of the etiology of diabetes mellitus.

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