Brain concentrations of phenytoin, phenobarbitone and primidone in epileptic patients.

European journal of clinical pharmacology ·Vol. 9 ·No. 1 ·1975-10-10 ·Pages 73-8

Houghton GW, Richens A, Toseland PA, Davidson S, Falconer

Abstract

Plasma, brain, lumbar CSF, skeletal muscle, skin and bone concentrations of phenytoin, phenobarbitone and primidone have been measured in specimens from patients undergoing temporal lobectomy for chronic epilepsy. A good correlation was found between the plasma and brain concentrations of each drug. Similarly, a good correlation was found between the plasma and CSF concentrations of each drug. Assuming that CSF is an ultrafiltrate of plasma, the percentage of phenytoin, phenobarbitone and primidone which was unbound in plasma was 10-14%, 43% and 81% respectively. Skeletal muscle concentrations of phenytoin and phenobarbitone and the skin concentration of phenytoin, also correlated with the plasma concentrations, but the remaining tissues did not give significant correlations.

MeSH Terms

Adolescent Adult Brain Chemistry Child Child, Preschool Chromatography, Gas Epilepsy, Temporal Lobe/metabolism Humans Phenobarbital/analysis,blood,cerebrospinal fluid Phenytoin/analysis,blood,cerebrospinal fluid Primidone/analysis,blood,cerebrospinal fluid

Chemicals

Primidone Phenytoin Phenobarbital

Authors & Affiliations

5 authors, click to expand affiliations / ORCID

Houghton G W

Richens A

Toseland P A

Davidson S

Falconer

References (12)

12 references, click to expand

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Article Info

Journal

European journal of clinical pharmacology

Abbr.

Eur J Clin Pharmacol

ISSN

0031-6970

DOI

10.1007/BF00613432

Published

1975-10-10

Pages

73-8

Language

English

Region

Germany

NLM ID

1256165

Subset

External Links

PubMed source DOI: 10.1007/BF00613432 View journal details

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Brain concentrations of phenytoin, phenobarbitone and primidone in epileptic patients.

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