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PMID: 123253 Published · ppublish English Journal Article

Sodium- and potassium-activated ATPase. A possible target of aldosterone.

The Journal of clinical investigation ·Vol. 55 ·No. 3 ·1975-03-00 ·Pages 655-60

Schmidt U, Schmid J, Schmid H, Dubach UC

Abstract

Na-K-ATPase activity was measured with an ultramicromethod in single portions of the proximal and distal convolution and of the thick ascending limb of Henle from adrenalectomized rats and after treatment with 5 mug aldosterone per 100 g body wt. The activity in all tubular structures returned to normal within 1 h after injection. This rapid activation of Na-K-ATPase induced by hormone was completely prevented by actinomycin D and cycloheximide. It appears that this aldosterone effect on Na-K-ATPase requires an intact protein synthetic process.

MeSH Terms
Adenosine Triphosphatases/metabolism Adrenalectomy Aldosterone/administration & dosage,pharmacology Animals Cycloheximide/pharmacology Dactinomycin/pharmacology Depression, Chemical Enzyme Activation/drug effects Kidney Tubules, Distal/drug effects,enzymology,metabolism Kidney Tubules, Proximal/drug effects,enzymology,metabolism Loop of Henle/enzymology,metabolism Male Nephrons/enzymology Potassium/metabolism,pharmacology Rats Sodium/metabolism,pharmacology
Chemicals
Dactinomycin Aldosterone Cycloheximide Sodium Adenosine Triphosphatases Potassium
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Schmidt U
Schmid J
Schmid H
Dubach U C
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Article Info
Journal
The Journal of clinical investigation
Abbr.
J Clin Invest
ISSN
0021-9738
DOI
10.1172/JCI107973
Published
1975-03-00
Pages
655-60
Language
English
Region
United States
NLM ID
7802877
PMCID
PMC301794
Subset
IM
External Links
PubMed source DOI: 10.1172/JCI107973 PMC Full Text View journal details
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