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PMID: 12235368 Published · ppublish English Journal Article Research Support, U.S. Gov't, Non-P.H.S. Research Support, U.S. Gov't, P.H.S.

Acceleration of genomic evolution caused by enhanced mutation rate in endocellular symbionts.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 99 ·No. 20 ·2002-10-01 ·Pages 12944-8

Itoh T, Martin W, Nei M

Abstract

Endosymbionts, which are widely observed in nature, have undergone reductive genome evolution because of their long-term intracellular lifestyle. Here we compared the complete genome sequences of two different endosymbionts, Buchnera and a protist mitochondrion, with their close relatives to study the evolutionary rates of functional genes in endosymbionts. The results indicate that the rate of amino acid substitution is two times higher in symbionts than in their relatives. This rate increase was observed uniformly among different functional classes of genes, although strong purifying selection may have counterbalanced the rate increase in a few cases. Our data suggest that, contrary to current views, neither the Muller's ratchet effect nor the slightly deleterious mutation theory sufficiently accounts for the elevated evolutionary rate. Rather, the elevated evolutionary rate appears to be mainly due to enhanced mutation rate, although the possibility of relaxation of purifying selection cannot be ruled out.

MeSH Terms
Buchnera/genetics Databases as Topic Escherichia coli/genetics Evolution, Molecular Haemophilus influenzae/genetics Mutation Phylogeny RNA, Ribosomal, 16S/metabolism
Chemicals
RNA, Ribosomal, 16S
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Itoh Takeshi
Institute of Molecular Evolutionary Genetics and Department of Biology, Pennsylvania State University, 328 Mueller Laboratory, University Park, PA 16802, USA.
Martin William
Nei Masatoshi
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Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.192449699
Published
2002-10-01
Epub
2002-00-16
Pages
12944-8
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC130565
Subset
IM
Grants
NIGMS NIH HHS · R01 GM020293 · United States
NIGMS NIH HHS · GM 20293 · United States
External Links
PubMed source DOI: 10.1073/pnas.192449699 PMC Full Text View journal details
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