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PMID: 12228721 Published · ppublish English Comparative Study Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

A stem cell molecular signature.

Science (New York, N.Y.) ·Vol. 298 ·No. 5593 ·2002-10-18 ·Pages 601-4

Ivanova NB, Dimos JT, Schaniel C, Hackney JA, Moore KA, Lemischka IR

Abstract

Mechanisms regulating self-renewal and cell fate decisions in mammalian stem cells are poorly understood. We determined global gene expression profiles for mouse and human hematopoietic stem cells and other stages of the hematopoietic hierarchy. Murine and human hematopoietic stem cells share a number of expressed gene products, which define key conserved regulatory pathways in this developmental system. Moreover, in the mouse, a portion of the genetic program of hematopoietic stem cells is shared with embryonic and neural stem cells. This overlapping set of gene products represents a molecular signature of stem cells.

MeSH Terms

Adult Animals Cell Communication Cell Cycle Cell Differentiation Cell Line Cell Lineage Cell Separation Cells, Cultured Computational Biology Embryo, Mammalian/cytology Expressed Sequence Tags Gene Expression Gene Expression Profiling Genes, Homeobox Hematopoiesis Hematopoietic Stem Cell Transplantation Hematopoietic Stem Cells/physiology Humans Mice Neurons/cytology Oligonucleotide Array Sequence Analysis Signal Transduction Stem Cells/physiology Totipotent Stem Cells/physiology Transcription, Genetic

Authors & Affiliations

6 authors, click to expand affiliations / ORCID

Ivanova Natalia B

Department of Molecular Biology, Princeton University, Princeton, NJ 08544, USA.

Dimos John T

Schaniel Christoph

Hackney Jason A

Moore Kateri A

Lemischka Ihor R

Article Info

Journal

Science (New York, N.Y.)

Abbr.

Science

ISSN

1095-9203

DOI

10.1126/science.1073823

Published

2002-10-18

Epub

2002-00-12

Pages

601-4

Language

English

Region

United States

NLM ID

0404511

Subset

Grants

NIDDK NIH HHS · DK42989 · United States

NIDDK NIH HHS · DK54493 · United States

Corrections

CommentIn

PMID: 14563977

CommentIn

PMID: 14563990

CommentIn

PMID: 14563991

External Links

PubMed source DOI: 10.1126/science.1073823 View journal details

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