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PMID: 12213957 Published · ppublish English Journal Article Research Support, U.S. Gov't, Non-P.H.S. Research Support, U.S. Gov't, P.H.S.

Type III secretion systems and the evolution of mutualistic endosymbiosis.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 99 ·No. 19 ·2002-09-17 ·Pages 12397-402

Dale C, Plague GR, Wang B, Ochman H, Moran NA

Abstract

The view that parasites can develop cooperative symbiotic relationships with their hosts is both appealing and widely held; however, there is no molecular genetic evidence of such a transition. Here we demonstrate that a mutualistic bacterial endosymbiont of grain weevils maintains and expresses inv/spa genes encoding a type III secretion system homologous to that used for invasion by bacterial pathogens. Phylogenetic analyses indicate that inv/spa genes were present in presymbiotic ancestors of the weevil endosymbionts, occurring at least 50 million years ago. The function of inv/spa genes in maintaining symbiosis is demonstrated by the up-regulation of their expression under both in vivo and in vitro conditions that coincide with host cell invasion.

MeSH Terms
Adhesins, Bacterial/genetics Animals Antigens, Bacterial/genetics Base Sequence Biological Evolution Cloning, Molecular Coleoptera/genetics,microbiology,physiology DNA, Bacterial/genetics Enterobacteriaceae/genetics,physiology Gene Expression Genes, Bacterial Molecular Sequence Data Phylogeny Symbiosis/genetics
Chemicals
Adhesins, Bacterial Antigens, Bacterial DNA, Bacterial streptococcal protective antigen invasin, Yersinia
Authors & Affiliations
5 authors, click to expand affiliations / ORCID
Dale Colin
Department of Ecology and Evolutionary Biology, Center for Insect Science, and Department of Biochemistry and Molecular Biophysics, University of Arizona, Tucson, AZ 85721.
Plague Gordon R
Wang Ben
Ochman Howard
Moran Nancy A
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Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.182213299
Published
2002-09-17
Epub
2002-00-04
Pages
12397-402
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC129456
Subset
IM
Grants
NIGMS NIH HHS · R01 GM056120 · United States
NIGMS NIH HHS · GM56120 · United States
Databases
GENBANK
AF426456, AF426457, AF426458, AF426459, AF426460, AF467290
External Links
PubMed source DOI: 10.1073/pnas.182213299 PMC Full Text View journal details
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