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Enhanced transformation by a plasma membrane-associated met oncoprotein: activation of a phosphoinositide 3'-kinase-dependent autocrine loop involving hyaluronic acid and CD44.
Mol Cell Biol. 2000 May;20(10):3482-96
PMID: 10779338
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Three isoforms of mammalian hyaluronan synthases have distinct enzymatic properties.
J Biol Chem. 1999 Aug 27;274(35):25085-92
PMID: 10455188
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Disruption of hyaluronan synthase-2 abrogates normal cardiac morphogenesis and hyaluronan-mediated transformation of epithelium to mesenchyme.
J Clin Invest. 2000 Aug;106(3):349-60
PMID: 10930438
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Hyaluronan in morphogenesis.
Semin Cell Dev Biol. 2001 Apr;12(2):79-87
PMID: 11292373
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Stromal and epithelial expression of tumor markers hyaluronic acid and HYAL1 hyaluronidase in prostate cancer.
J Biol Chem. 2001 Apr 13;276(15):11922-32
PMID: 11278412
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Hyaluronan synthase elevation in metastatic prostate carcinoma cells correlates with hyaluronan surface retention, a prerequisite for rapid adhesion to bone marrow endothelial cells.
J Biol Chem. 2001 May 25;276(21):17949-57
PMID: 11278609
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Hyaluronan activates cell motility of v-Src-transformed cells via Ras-mitogen-activated protein kinase and phosphoinositide 3-kinase-Akt in a tumor-specific manner.
Mol Biol Cell. 2001 Jun;12(6):1859-68
PMID: 11408591
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Hyaluronan synthase 3 overexpression promotes the growth of TSU prostate cancer cells.
Cancer Res. 2001 Jul 1;61(13):5207-14
PMID: 11431361
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CD44-mediated oncogenic signaling and cytoskeleton activation during mammary tumor progression.
J Mammary Gland Biol Neoplasia. 2001 Jul;6(3):287-97
PMID: 11547898
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Hyaluronan enters keratinocytes by a novel endocytic route for catabolism.
J Biol Chem. 2001 Sep 14;276(37):35111-22
PMID: 11451952
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CD44 acts both as a growth- and invasiveness-promoting molecule and as a tumor-suppressing cofactor.
Ann N Y Acad Sci. 2000 Jun;910:106-18; discussion 118-20
PMID: 10911909
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Peptides that mimic glycosaminoglycans: high-affinity ligands for a hyaluronan binding domain.
Chem Biol. 2001 Nov;8(11):1081-94
PMID: 11731299
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CD44-mediated uptake and degradation of hyaluronan.
Matrix Biol. 2002 Jan;21(1):15-23
PMID: 11827788
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Hyaluronan-binding proteins: tying up the giant.
J Biol Chem. 2002 Feb 15;277(7):4585-8
PMID: 11717315
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Signaling properties of hyaluronan receptors.
J Biol Chem. 2002 Feb 15;277(7):4589-92
PMID: 11717317
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Hyaluronan-cell interactions in cancer and vascular disease.
J Biol Chem. 2002 Feb 15;277(7):4593-6
PMID: 11717318
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Manipulation of hyaluronan synthase expression in prostate adenocarcinoma cells alters pericellular matrix retention and adhesion to bone marrow endothelial cells.
J Biol Chem. 2002 Mar 22;277(12):10050-7
PMID: 11790779
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Abnormal accumulation of hyaluronan matrix diminishes contact inhibition of cell growth and promotes cell migration.
Proc Natl Acad Sci U S A. 2002 Mar 19;99(6):3609-14
PMID: 11891291
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Resolution of lung inflammation by CD44.
Science. 2002 Apr 5;296(5565):155-8
PMID: 11935029
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Hyaluronan promotes the malignant phenotype.
Glycobiology. 2002 Mar;12(3):37R-42R
PMID: 11971857
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Overexpression of hyaluronan synthase-2 reduces the tumorigenic potential of glioma cells lacking hyaluronidase activity.
Neurosurgery. 2002 Jun;50(6):1311-8
PMID: 12015850
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Changed lamellipodial extension, adhesion plaques and migration in epidermal keratinocytes containing constitutively expressed sense and antisense hyaluronan synthase 2 (Has2) genes.
J Cell Sci. 2002 Sep 15;115(Pt 18):3633-43
PMID: 12186949
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Inhibition of prostate tumor cell hyaluronan synthesis impairs subcutaneous growth and vascularization in immunocompromised mice.
Am J Pathol. 2002 Sep;161(3):849-57
PMID: 12213713
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Hyaluronan and angiogenesis.
Ciba Found Symp. 1989;143:187-201; discussion 201-7, 281-5
PMID: 2478344
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The role of hyaluronan in tumour neovascularization (review).
Int J Cancer. 1995 Mar 3;60(5):632-6
PMID: 7532158
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Expression of hyaluronidase by tumor cells induces angiogenesis in vivo.
Proc Natl Acad Sci U S A. 1996 Jul 23;93(15):7832-7
PMID: 8755562
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Selective suppression of CD44 in keratinocytes of mice bearing an antisense CD44 transgene driven by a tissue-specific promoter disrupts hyaluronate metabolism in the skin and impairs keratinocyte proliferation.
Genes Dev. 1997 Apr 15;11(8):996-1007
PMID: 9136928
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Hyaluronan: fundamental principles and applications in cancer.
J Intern Med. 1997 Jul;242(1):41-8
PMID: 9260565
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Induction of apoptosis of metastatic mammary carcinoma cells in vivo by disruption of tumor cell surface CD44 function.
J Exp Med. 1997 Dec 15;186(12):1985-96
PMID: 9396767
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Inhibition of tumor growth in vivo by hyaluronan oligomers.
Int J Cancer. 1998 Jul 29;77(3):396-401
PMID: 9663602
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Overproduction of hyaluronan by expression of the hyaluronan synthase Has2 enhances anchorage-independent growth and tumorigenicity.
Cancer Res. 1999 Mar 1;59(5):1141-5
PMID: 10070975
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Relationship between hyaluronan production and metastatic potential of mouse mammary carcinoma cells.
Cancer Res. 1999 May 15;59(10):2499-504
PMID: 10344764