Role of the tof gene in the production and perpetuation of the lambdadv plasmid.

Molecular & general genetics : MGG ·Vol. 142 ·No. 3 ·1975-12-30 ·Pages 225-30

Matsubara K, Takeda Y

Abstract

A series of lambda derivatives carrying tof mutations were tested for their ability to give rise to plasmid lambda dv. Phages carrying tof mutations that distorted expression of the pRoR-tof-OP operon, were unable to produce lambda dv. Phages carrying an altered tof gene, having only a moderate effect on the same operon, produced unstable lambdadv's. On the other hand, those tof mutants were only the expression of the pLoL-N-exo operon, but not that of the pRoR-tof-OP operon was affected, produced stable lambdadv's.

MeSH Terms

Coliphages/metabolism DNA/metabolism DNA Replication Extrachromosomal Inheritance Genotype Mutation Operon Plasmids Transcription, Genetic

Chemicals

DNA

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Matsubara K

Takeda Y

References (11)

11 references, click to expand

Lambda dv: an autonomously replicating DNA fragment.
Cold Spring Harb Symp Quant Biol. 1968;33:769-75 PMID: 4892008
Genetic structure and regulation of a replicon of plasmid lambdadv.
J Mol Biol. 1976 Apr 15;102(3):427-39 PMID: 1271469
Genes of phage lambda essential for lambda dv plasmids.
Virology. 1974 Nov;62(1):224-33 PMID: 4609081
Two repressors in bacteriophage lambda.
Mol Gen Genet. 1973 Jan 24;120(2):133-7 PMID: 4686213
Regulation of repressor expression in lambda.
Proc Natl Acad Sci U S A. 1970 Jul;66(3):855-62 PMID: 5269249
Interference in phage growth by a resident plasmid lambda dv. I. The mode of interference.
Virology. 1972 Dec;50(3):713-26 PMID: 4565612
Location of the phage lambda gene responsible for turning off lambda-exonuclease synthesis.
Virology. 1970 Jan;40(1):65-71 PMID: 5411194
Regulation of early gene expression in bacteriophage lambda: effect of tof mutation on strand-specific transcriptions.
Virology. 1975 Jun;65(2):374-84 PMID: 1129947
Studies on lambda virulent mutants. I. Isolation and characterization of revertants from lambdavirC mutant.
Mol Gen Genet. 1972;118(3):287-94 PMID: 4563168
Role of the cro gene in bacteriophage lambda development.
J Mol Biol. 1973 Oct 25;80(2):203-16 PMID: 4587402
Preparation of plasmid lambda dv from bacteriophage lambda: role of promoter-operator in the plasmid replicon.
J Virol. 1974 Mar;13(3):596-602 PMID: 4595898

Article Info

Journal

Molecular & general genetics : MGG

Abbr.

Mol Gen Genet

ISSN

0026-8925

DOI

10.1007/BF00425647

Published

1975-12-30

Pages

225-30

Language

English

Region

Germany

NLM ID

0125036

Subset

External Links

PubMed source DOI: 10.1007/BF00425647

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Role of the tof gene in the production and perpetuation of the lambdadv plasmid.

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