Home LiteratureArticle Details
PMID: 12208857 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S. Review

Cholesterol modification of Hedgehog family proteins.

The Journal of clinical investigation ·Vol. 110 ·No. 5 ·2002-09-00 ·Pages 591-6

Jeong J, McMahon AP

Abstract

暂无摘要

MeSH Terms
Animals Caenorhabditis elegans Cell Division Cholesterol/metabolism Drosophila Proteins/metabolism Hedgehog Proteins Lipid Metabolism Mice Models, Biological Models, Chemical Palmitic Acids/metabolism
Chemicals
Drosophila Proteins Hedgehog Proteins Palmitic Acids hh protein, Drosophila Cholesterol
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Jeong Juhee
Department of Molecular and Cellular Biology, The Biolabs, Harvard University, Cambridge, Massachusetts 02138, USA.
McMahon Andrew P
References (57)
57 references, click to expand
  1. Dual roles for patched in sequestering and transducing Hedgehog.
    Cell. 1996 Nov 1;87(3):553-63 PMID: 8898207
  2. Cholesterol modification of sonic hedgehog is required for long-range signaling activity and effective modulation of signaling by Ptc1.
    Cell. 2001 Jun 1;105(5):599-612 PMID: 11389830
  3. The Hedgehog and Wnt signalling pathways in cancer.
    Nature. 2001 May 17;411(6835):349-54 PMID: 11357142
  4. Enhanced potency of human Sonic hedgehog by hydrophobic modification.
    Biochemistry. 2001 Apr 10;40(14):4359-71 PMID: 11284692
  5. The teratogenic Veratrum alkaloid cyclopamine inhibits sonic hedgehog signal transduction.
    Development. 1998 Sep;125(18):3553-62 PMID: 9716521
  6. Multiple roles of cholesterol in hedgehog protein biogenesis and signaling.
    Cold Spring Harb Symp Quant Biol. 1997;62:191-204 PMID: 9598352
  7. Rasp, a putative transmembrane acyltransferase, is required for Hedgehog signaling.
    Development. 2002 Feb;129(4):843-51 PMID: 11861468
  8. Dispatched, a novel sterol-sensing domain protein dedicated to the release of cholesterol-modified hedgehog from signaling cells.
    Cell. 1999 Dec 23;99(7):803-15 PMID: 10619433
  9. Proteolytic processing yields two secreted forms of sonic hedgehog.
    Mol Cell Biol. 1995 Apr;15(4):2294-303 PMID: 7891723
  10. Sequential organizing activities of engrailed, hedgehog and decapentaplegic in the Drosophila wing.
    Development. 1995 Aug;121(8):2265-78 PMID: 7671794
  11. The whereabouts of a morphogen: direct evidence for short- and graded long-range activity of hedgehog signaling peptides.
    Dev Biol. 2001 Aug 15;236(2):364-86 PMID: 11476578
  12. A hedgehog-insensitive form of patched provides evidence for direct long-range morphogen activity of sonic hedgehog in the neural tube.
    Mol Cell. 2001 Jun;7(6):1279-91 PMID: 11430830
  13. Cyclopia and defective axial patterning in mice lacking Sonic hedgehog gene function.
    Nature. 1996 Oct 3;383(6599):407-13 PMID: 8837770
  14. Floor plate and motor neuron induction by different concentrations of the amino-terminal cleavage product of sonic hedgehog autoproteolysis.
    Cell. 1995 May 5;81(3):445-55 PMID: 7736596
  15. Argosomes: a potential vehicle for the spread of morphogens through epithelia.
    Cell. 2001 Sep 7;106(5):633-45 PMID: 11551510
  16. The seven-transmembrane receptor smoothened cell-autonomously induces multiple ventral cell types.
    Nat Neurosci. 2000 Jan;3(1):41-6 PMID: 10607393
  17. A freely diffusible form of Sonic hedgehog mediates long-range signalling.
    Nature. 2001 Jun 7;411(6838):716-20 PMID: 11395778
  18. Wingless and Hedgehog pattern Drosophila denticle belts by regulating the production of short-range signals.
    Development. 1999 Dec;126(24):5689-98 PMID: 10572045
  19. Mutations in the human Sonic Hedgehog gene cause holoprosencephaly.
    Nat Genet. 1996 Nov;14(3):357-60 PMID: 8896572
  20. Neuronal specification in the spinal cord: inductive signals and transcriptional codes.
    Nat Rev Genet. 2000 Oct;1(1):20-9 PMID: 11262869
  21. Protein lipidation in cell signaling.
    Science. 1995 Apr 14;268(5208):221-5 PMID: 7716512
  22. Skinny hedgehog, an acyltransferase required for palmitoylation and activity of the hedgehog signal.
    Science. 2001 Sep 14;293(5537):2080-4 PMID: 11486055
  23. Hedgehog signaling in animal development: paradigms and principles.
    Genes Dev. 2001 Dec 1;15(23):3059-87 PMID: 11731473
  24. Teratogen-mediated inhibition of target tissue response to Shh signaling.
    Science. 1998 Jun 5;280(5369):1603-7 PMID: 9616123
  25. Association of sterol- and glycosylphosphatidylinositol-linked proteins with Drosophila raft lipid microdomains.
    J Biol Chem. 1999 Apr 23;274(17):12049-54 PMID: 10207028
  26. Caenorhabditis elegans has scores of hedgehog-related genes: sequence and expression analysis.
    Genome Res. 1999 Oct;9(10):909-23 PMID: 10523520
  27. Developmental roles and clinical significance of hedgehog signaling.
    Curr Top Dev Biol. 2003;53:1-114 PMID: 12509125
  28. The sterol-sensing domain of Patched protein seems to control Smoothened activity through Patched vesicular trafficking.
    Curr Biol. 2001 Apr 17;11(8):601-7 PMID: 11369205
  29. The product of hedgehog autoproteolytic cleavage active in local and long-range signalling.
    Nature. 1995 Mar 23;374(6520):363-6 PMID: 7885476
  30. Cholesterol modification of hedgehog signaling proteins in animal development.
    Science. 1996 Oct 11;274(5285):255-9 PMID: 8824192
  31. Sightless has homology to transmembrane acyltransferases and is required to generate active Hedgehog protein.
    Curr Biol. 2001 Jul 24;11(14):1147-52 PMID: 11509241
  32. A Hedgehog activity gradient contributes to AP axial patterning of the Drosophila wing.
    Development. 1997 Nov;124(22):4697-705 PMID: 9409685
  33. Identification of a palmitic acid-modified form of human Sonic hedgehog.
    J Biol Chem. 1998 May 29;273(22):14037-45 PMID: 9593755
  34. Functional rafts in cell membranes.
    Nature. 1997 Jun 5;387(6633):569-72 PMID: 9177342
  35. Hedgehog activity, independent of decapentaplegic, participates in wing disc patterning.
    Development. 1997 Mar;124(6):1227-37 PMID: 9102309
  36. Cholesterol, lipid rafts, and disease.
    J Clin Invest. 2002 Sep;110(5):597-603 PMID: 12208858
  37. Vertebrate Hedgehog signalling modulated by induction of a Hedgehog-binding protein.
    Nature. 1999 Feb 18;397(6720):617-21 PMID: 10050855
  38. Autoproteolysis in hedgehog protein biogenesis.
    Science. 1994 Dec 2;266(5190):1528-37 PMID: 7985023
  39. Genetics of morphogen gradients.
    Nat Rev Genet. 2001 Aug;2(8):620-30 PMID: 11483986
  40. Relationship between dose, distance and time in Sonic Hedgehog-mediated regulation of anteroposterior polarity in the chick limb.
    Development. 1997 Nov;124(21):4393-404 PMID: 9334287
  41. Mutations in the sterol-sensing domain of Patched suggest a role for vesicular trafficking in Smoothened regulation.
    Curr Biol. 2001 Apr 17;11(8):608-13 PMID: 11369206
  42. Hedgehog movement is regulated through tout velu-dependent synthesis of a heparan sulfate proteoglycan.
    Mol Cell. 1999 Oct;4(4):633-9 PMID: 10549295
  43. Sonic hedgehog mediates the polarizing activity of the ZPA.
    Cell. 1993 Dec 31;75(7):1401-16 PMID: 8269518
  44. Crystal structure of a Hedgehog autoprocessing domain: homology between Hedgehog and self-splicing proteins.
    Cell. 1997 Oct 3;91(1):85-97 PMID: 9335337
  45. Effects of oncogenic mutations in Smoothened and Patched can be reversed by cyclopamine.
    Nature. 2000 Aug 31;406(6799):1005-9 PMID: 10984056
  46. Receptor-mediated endocytosis of soluble and membrane-tethered Sonic hedgehog by Patched-1.
    Proc Natl Acad Sci U S A. 2000 Oct 24;97(22):12044-9 PMID: 11027307
  47. N-terminal fatty-acylation of sonic hedgehog enhances the induction of rodent ventral forebrain neurons.
    Development. 2001 Jun;128(12):2351-63 PMID: 11493554
  48. Distinct consequences of sterol sensor mutations in Drosophila and mouse patched homologs.
    Dev Biol. 2002 Feb 15;242(2):224-35 PMID: 11820817
  49. Tout-velu is a Drosophila homologue of the putative tumour suppressor EXT-1 and is needed for Hh diffusion.
    Nature. 1998 Jul 2;394(6688):85-8 PMID: 9665133
  50. Shaping morphogen gradients.
    Cell. 2001 Jun 1;105(5):559-62 PMID: 11389824
  51. The sonic hedgehog receptor patched associates with caveolin-1 in cholesterol-rich microdomains of the plasma membrane.
    J Biol Chem. 2001 Jun 1;276(22):19503-11 PMID: 11278759
  52. Hedgehog patterning activity: role of a lipophilic modification mediated by the carboxy-terminal autoprocessing domain.
    Cell. 1996 Jul 12;86(1):21-34 PMID: 8689684
  53. Distinct roles of Central missing and Dispatched in sending the Hedgehog signal.
    Development. 2001 Dec;128(24):5119-27 PMID: 11748147
  54. A homeodomain protein code specifies progenitor cell identity and neuronal fate in the ventral neural tube.
    Cell. 2000 May 12;101(4):435-45 PMID: 10830170
  55. Hedgehog signaling: a tale of two lipids.
    Science. 2001 Nov 30;294(5548):1879-81 PMID: 11729305
  56. An acylatable residue of Hedgehog is differentially required in Drosophila and mouse limb development.
    Dev Biol. 2001 May 1;233(1):122-36 PMID: 11319862
  57. Inhibition of sonic hedgehog autoprocessing in cultured mammalian cells by sterol deprivation.
    Proc Natl Acad Sci U S A. 2000 Jun 20;97(13):7307-12 PMID: 10860995
Article Info
Journal
The Journal of clinical investigation
Abbr.
J Clin Invest
ISSN
0021-9738
DOI
10.1172/JCI16506
Published
2002-09-00
Pages
591-6
Language
English
Region
United States
NLM ID
7802877
PMCID
PMC151115
Subset
IM
Grants
NINDS NIH HHS · R01 NS033642 · United States
NINDS NIH HHS · R37 NS033642 · United States
NIDDK NIH HHS · DK-56246 · United States
NIDDK NIH HHS · P01 DK056246 · United States
NINDS NIH HHS · NS-33642 · United States
External Links
PubMed source DOI: 10.1172/JCI16506 PMC Full Text View journal details
Analysis Services
Analysis Services

Contact

No. 2 Wenbo Road, Zhangqiu District, Jinan, Shandong

Qilu Normal University · Genelibs Bioinformatics Lab

750 Shunhua Rd, Jinan

2F, Bldg F, University Science Park

Tel: 0531-88819269

WeChat Official Account

Follow our WeChat subscription account for real-time updates and the latest in medical and biological research.


Business Email

E-mail: product@genelibs.com

Copyright © 2026.Genelibs Jinan Honghui Biotechnology Co., Ltd. 鲁ICP备20007159号-2