Macrophage apoptosis by anthrax lethal factor through p38 MAP kinase inhibition.

Animals Antigens, Bacterial Apoptosis Bacterial Toxins/toxicity Calcium-Calmodulin-Dependent Protein Kinases/genetics,metabolism Carrier Proteins/toxicity Cell Line Enzyme Activation Enzyme Inhibitors/pharmacology Gene Expression I-kappa B Kinase Imidazoles/pharmacology Lipopolysaccharides/pharmacology MAP Kinase Kinase 3 MAP Kinase Kinase 6 MAP Kinase Signaling System Macrophage Activation Macrophages/enzymology,immunology,physiology Mice Mice, Inbred C57BL Mitogen-Activated Protein Kinase Kinases/genetics,metabolism Mitogen-Activated Protein Kinases/antagonists & inhibitors,metabolism NF-kappa B/genetics,metabolism Necrosis Protein Serine-Threonine Kinases/genetics,metabolism Protein-Tyrosine Kinases/genetics,metabolism Pyridines/pharmacology Teichoic Acids/pharmacology Transcription Factor RelA p38 Mitogen-Activated Protein Kinases

Antigens, Bacterial Bacterial Toxins Carrier Proteins Enzyme Inhibitors Imidazoles Lipopolysaccharides NF-kappa B Pyridines Teichoic Acids Transcription Factor RelA anthrax toxin lipoteichoic acid Protein-Tyrosine Kinases Protein Serine-Threonine Kinases Chuk protein, mouse I-kappa B Kinase Ikbkb protein, mouse Ikbke protein, mouse Calcium-Calmodulin-Dependent Protein Kinases Mitogen-Activated Protein Kinases p38 Mitogen-Activated Protein Kinases MAP Kinase Kinase 3 MAP Kinase Kinase 6 Map2k3 protein, mouse Map2k6 protein, mouse Mitogen-Activated Protein Kinase Kinases 4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole