Competition and compensation: coupled to death in development and cancer.

Cell ·Vol. 110 ·No. 4 ·2002-08-23 ·Pages 403-6

Abrams JM

Abstract

Developing systems exhibit robust and tolerant properties in the form of compensation and competition within cell groups. Fundamentally, these behaviors are governed by mechanisms that elicit proliferation and apoptosis. Recent insights from the Drosophila system implicate new determinants that specify "winners" and "losers" in this process.

MeSH Terms

Animals Apoptosis/genetics Body Patterning/genetics Cell Communication/genetics Cell Differentiation/genetics Cell Division/genetics Drosophila Proteins/genetics Eukaryotic Cells/cytology,metabolism Gene Expression Regulation, Developmental/genetics Humans Neoplasms/genetics,metabolism,physiopathology

Chemicals

Drosophila Proteins

Authors & Affiliations

1 authors, click to expand affiliations / ORCID

Abrams John M

Department of Cell Biology, University of Texas Southwestern Medical Center, 75390, USA. john.abrams@utsouthwestern.edu

Article Info

Journal

Cell

Abbr.

Cell

ISSN

0092-8674

DOI

10.1016/s0092-8674(02)00904-2

john.abrams@utsouthwestern.edu

Published

2002-08-23

Pages

403-6

Language

English

Region

United States

NLM ID

0413066

Subset

Corrections

CommentOn

PMID: 12202036

External Links

PubMed source DOI: 10.1016/s0092-8674(02)00904-2 View journal details

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Competition and compensation: coupled to death in development and cancer.

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